Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Knipe H, Deng F, et al. Botryoid rhabdomyosarcoma. Reference article, Radiopaedia.org (Accessed on 05 Dec 2024) https://doi.org/10.53347/rID-7851
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Botryoid rhabdomyosarcoma, also known as sarcoma botryoides, is a type of embryonal rhabdomyosarcoma and accounts for 5-10% of all rhabdomyosarcomas 6.
It tends to occur in pediatric population, often between birth and 15 years of age 7.
Rhabdomyosarcomas generally have a nonspecific infiltrative appearance. The botryoid variant is unusual in that it manifests as a polypoid or "grape-like lesion" beneath the mucosa. It does not infiltrate the epithelium and is described as having an intratubular appearance 5.
Distribution
They occur principally beneath a mucous membrane 3,6. Recognized sites of occurrence include:
With vaginal and urinary bladder locations being the most common.
MRI
Lesions can be large. Signal characteristics are similar to rhabdomyosarcoma i.e 1:
T1: low to intermediate
T2: high
Grapelike intraluminal masses would favor a botryoides type.
History and etymology
Botryoid, derived from the Greek bótry(s) for grape, means resembling the form of grapes.
Macroscopic differential diagnoses for the vaginal and urinary bladder locations based on the polypoid appearance include 5:
yolk sac tumor
tumoral cystits
For the pelvic/presacral region consider:
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1. Wong-You-Cheong J, Woodward P, Manning M, Sesterhenn I. From the Archives of the AFIP: Neoplasms of the Urinary Bladder: Radiologic-Pathologic Correlation. Radiographics. 2006;26(2):553-80. doi:10.1148/rg.262055172 - Pubmed
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2. Houghton J & McCluggage W. Embryonal Rhabdomyosarcoma of the Cervix with Focal Pleomorphic Areas. J Clin Pathol. 2007;60(1):88-9. doi:10.1136/jcp.2005.034769 - Pubmed
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3. Foxx S, Smoker W, Ghatak N, Kransdorf M. Primary Rhabdomyosarcoma of the Scalp. AJNR Am J Neuroradiol. 1995;16(7):1511-3. PMC8338062 - Pubmed
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4. Donnelly L, Bisset G, Frush D. Diagnosis Please. Case 2: Embryonal Rhabdomyosarcoma of the Biliary Tree. Radiology. 1998;208(3):621-3. doi:10.1148/radiology.208.3.9722837 - Pubmed
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5. Agrons G, Wagner B, Lonergan G, Dickey G, Kaufman M. From the Archives of the AFIP. Genitourinary Rhabdomyosarcoma in Children: Radiologic-Pathologic Correlation. Radiographics. 1997;17(4):919-37. doi:10.1148/radiographics.17.4.9225391 - Pubmed
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6. Arthur M. de Schepper. Imaging of Soft Tissue Tumors. (2005) ISBN: 9783540248095 - Google Books
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7. Mark J. Kransdorf, Mark D. Murphey. Imaging of Soft Tissue Tumors. (2006) ISBN: 9780781747714 - Google Books
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