Citation, DOI, disclosures and article data
Citation:
Gaillard F, Worsley C, Gershon A, et al. BRAF. Reference article, Radiopaedia.org (Accessed on 16 Feb 2025) https://doi.org/10.53347/rID-45462
BRAF (B-Raf proto-oncogene serine/threonine-protein kinase) is a proto-oncogene, encoding for a serine/threonine protein kinase. Mutations of BRAF are the most common alteration of the RAS/MAPK pathway and these have been identified in a variety of tumors and congenital syndromes including 1-5:
- tumors
- congenital syndromes
Mutations
A variety of mutations are recognized, the most commonly encountered being:
- BRAF V600E point mutation (most common)
- BRAF fusion (KIAA1549:BRAF fusion)
-
1. BRAF B-Raf proto-oncogene, serine/threonine kinase [Homo sapiens (human)]
- www.ncbi.nlm.nih.gov. Read relevant article. Accessed on 26/05/2016
-
2. Dias-Santagata D, Lam Q, Vernovsky K et al. BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications. PLoS One. 2011;6(3):e17948. doi:10.1371/journal.pone.0017948 - Pubmed
-
3. International Agency for Research on Cancer, Otmar D. Wiestler. WHO Classification of Tumours of the Central Nervous System. (2016) ISBN: 9789283244929 - Google Books
-
4. AlRayahi J, Zapotocky M, Ramaswamy V et al. Pediatric Brain Tumor Genetics: What Radiologists Need to Know. Radiographics. 2018;38(7):2102-22. doi:10.1148/rg.2018180109 - Pubmed
-
5. BRAF gene, Genetics Home Reference, US National Library of Medicine Read Online Accessed Nov 27 2018.
Related articles: Radiogenomics
Promoted articles (advertising)