Brain arteriovenous malformation

Brain arteriovenous malformations are a type of intracranial high-flow vascular malformation composed of enlarged feeding arteries, a nidus of vessels closely associated with the brain parenchyma through which arteriovenous shunting occurs and draining veins.

Terminology

This article corresponds to the classic form of arteriovenous malformation involving the brain parenchyma. The term brain arteriovenous malformation (BAVM) is the preferred term ¹². An alternative is cerebral arteriovenous malformation (CAVM), but the term cerebral leaves out more caudal brain structures and the abbreviation could be confused with cavernous malformation. It is also referred to as a pial arteriovenous malformation if it is related to the pial vessels, but this is not always the case ⁶.

These malformations are characterized by a nidus forming the transition between the feeding artery and the draining vein. If this transition is made directly, then it is considered an arteriovenous fistula, which is a separate type of cerebral vascular anomaly.

Epidemiology

Although arteriovenous malformations are thought to represent a congenital abnormality, they are rarely found incidentally in the very young and many de novo lesions have been described amongst adults¹⁷. They are thought to expand over time. Despite this, a third of arteriovenous malformations that are diagnosed due to hemorrhage are identified before the age of 20 years ⁷. Overall, they are diagnosed at a mean age of 31 years ⁸.

Arteriovenous malformations are thought to occur in approximately 0.05% of the population¹⁶. There is no gender predilection ⁸.

AVMs tend to be solitary in the vast majority of cases (>95%). When multiple, syndromic associations must be considered, including:

• hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome)

• Wyburn-Mason syndrome (craniofacial arteriovenous metameric syndrome)

Clinical presentation

Cerebral arteriovenous malformations are the most common symptomatic vascular malformations. Possible presentations include ³:

• incidental finding in asymptomatic patients: 15% ⁵

• seizures: 20%

• headaches

• focal neurological deficit ¹⁵

• hemorrhage: 65% ⁵, incidence 2-3% per year ³

  • parenchymal

  • subarachnoid

  • intraventricular

Pathology

The origin of arteriovenous malformations remains uncertain, although they are thought to be multifactorial and often attributed to being congenital ³. Their development may involve dysregulation of vascular endothelium growth factor (VEGF) receptor-mediated endothelial proliferation and cytokine-mediated vessel remodeling ¹.

Arteriovenous malformations comprise a number of components ¹³:

• feeding arteries

• nidus (Latin for "nest")

  • shunting arterioles: the true culprit

  • interconnected venous loops

• draining veins

The nidus is fed by one or more arteries and drained by one or more veins. The feeding arteries are enlarged due to the low resistance (as blood bypasses the capillary beds) and therefore increased flow, which may lead to flow-related arterial aneurysms ³. Venous aneurysms, also referred to as venous pouches, may be seen as well. Arteriovenous malformations may contain dystrophic calcification, a small amount of gliotic tissue, or blood at different stages of aging ¹³. Early draining veins during the arterial phase of cerebral angiography signify the presence of an arteriovenous shunt ¹³.

Location

• supratentorial: ~85%

  • superficial (two-thirds)

  • deep (one-third)

• infratentorial: ~15%

Incidence

• solitary AVMs (98%)

• multiple AVMs (2%)

  • often associated with syndromes

Associated abnormalities

• flow-related angiopathy secondary to endothelial hyperplasia

• flow-related aneurysm

  • intranidal: located in the nidus

  • intrapedicular: located in the feeding vessel

• remote aneurysm: haemodynamically unrelated to malformation

Classification and grading

Brain arteriovenous malformations can be divided into two types ^4,6:

• compact (or glomerular) nidus: abnormal vessels without any interposed normal brain tissue. More common than diffuse nidus type

• diffuse (or proliferative) nidus: no well-formed nidus is present, with functional neuronal tissue interspersed amongst the anomalous vessels

  • when early venous drainage is absent, this is considered cerebral proliferative angiopathy ^6,9

The Spetzler-Martin AVM grading system relates morphology and location to the risk of surgery.

Radiographic features

CT

Diagnosis can be difficult on non-contrast CT. The nidus is blood density and therefore usually somewhat hyperdense compared to adjacent brain. Enlarged draining veins may be seen. Although they might be very large in size, they do not cause any mass effect unless they bleed.

Following contrast administration, and especially with CTA, the diagnosis is usually self-evident, with feeding arteries, draining veins, and intervening nidus visible in the so-called "bag of worms" appearance. The exact anatomy of feeding vessels and draining veins can be difficult to delineate, so angiography remains necessary.

Angiography (DSA)

Cerebral angiography remains the gold standard, able to exquisitely delineate the location and number of feeding vessels and the pattern of drainage. Ideally, angiography is performed in a bi-plane system with a high rate of acquisition, as shunting can be very rapid.

On angiography, an arteriovenous malformation appears as a tightly packed mass of enlarged feeding arteries that supply a central nidus. One or more dilated veins drain the nidus and abnormal opacification of veins occurs in the arterial phase (early venous drainage), represents shunting.

MRI

Fast flow generates flow voids, easily seen on T2 weighted images. Complications, including previous hemorrhage and adjacent edema, may be evident.

• MRA: phase-contrast MR angiography is often useful for subtracting the hematoma components when an arteriovenous malformation complicated by an acute hemorrhage needs to be imaged

Radiology report

Radiology reports should include certain key points that help the clinician in deciding the management and the anticipated risk associated with treatment ⁶.

 Radiological evidence of previous hemorrhage is the most important predictor of future hemorrhage, it is therefore important to distinguish AVMs that have bled from those that have not bled ⁶.

Angioarchitectural weakpoints due to intranidal aneurysm, ectasia or stenosis of draining veins, single draining vein or deep draining vein, or deep or posterior fossa location of the arteriovenous malformation is associated with a high risk of future hemorrhage and also need to be commented on ⁶.

Risk of non-hemorrhagic complications like focal neurological deficit increases with a high flow shunt, venous congestion or obstruction, a long pial course of a draining vein, arterial steal, mass effect, hydrocephalus and perinidal gliosis ⁶.

Treatment and prognosis

Treatment options and rate of complications are dictated in part by the Spetzler-Martin grade. In general, the three options available are:

1. microsurgical resection

2. endovascular occlusion

3. radiosurgery

Occasionally, arteriovenous malformations have been known to spontaneously resolve ², usually in the setting of intracranial hemorrhage, resulting presumably in venous compression and thrombosis. The annual risk of hemorrhage for an untreated arteriovenous malformation is 2-3%, resulting from a flow-related aneurysm, intra-nidal aneurysm, or venous thrombosis (rarely). Smaller arteriovenous malformations (≤3 cm) are at greater risk of hemorrhage due to the higher pressure of the feeding artery ¹⁴.

Following hemorrhage, the risk of a further bleed in the next 12 months is up to 18% ⁵.

Differential diagnosis

Imaging differential considerations include:

• other cerebral vascular malformations

  • cerebral proliferative angiopathy ^6,9

    • absence of early venous drainage

    • often, an entire lobe or even hemisphere is affected

    • feeder arteries tend to be of normal size or moderately enlarged

    • associated stenosis of feeder arteries is often present

  • craniofacial arteriovenous metameric syndrome (CAMS):

    • classic locations

    • association with facial AVM

  • dural arteriovenous fistula (DAVF)

  • developmental venous anomaly (DVA)

• vascular tumor

• glioblastoma