Breast amyloidosis

Amyloid deposition in the breast is predominantly of two forms 

 

  • breast involvement in primary amyloidosis - commoner
  • in association with other conditions like multiple myeloma, plasmacytosis and rheumatoid arthritis and another in the localised form which is rarer. 
  • usually seen in elderly patients
  • painless, solitary firm or hard mass (amyloidoma)

Amyloidosis is a systemic disease which is characterized by extracellular deposition of various insoluble proteins which may get deposited in any part of the body including breast.

The mass (or amyloidoma) is composed of amyloid deposits which are found predominantly around the ducts and blood vessels. The amyloid deposits are clearly demonstrated with Congo red staining.

Nearly 80% is seen in right breast ref required. But it can be unilateral or bilateral. 

Mammography

It may be seen as 

  • spiculated high density area
  • amorphous microcalcifications

Amyloidosis in the breast was first reported by BB Fernandez and FJ Hernandez in 1973 3.

Breast imaging and pathology
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Article Information

rID: 25690
System: Breast
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Amyloidosis of breast
  • Amyloidosis of the breast
  • Amyloidosis involving the breast

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