Breast calcifications (an approach)
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At the time the article was created Avni K P Skandhan had no recorded disclosures.View Avni K P Skandhan's current disclosures
An approach to breast calcifications in terms of imaging evaluation and biopsy aims to distinguish benign from malignant etiologies. This article overviews a general approach to the evaluation of breast calcifications. The types and descriptors of calcifications are detailed separately: breast calcifications.
- fine linear or fine-linear branching
- fine pleomorphic
- coarse heterogeneous
- typically benign
Small calcifications (<200 μm in diameter) are mostly malignant.
Calcifications stable for greater than 2 years can be considered benign.
The greater the number of microcalcifications in a small area, the more suspicious for malignancy.
At screening mammography, comparison should be made with prior studies to establish benignity through long term stability (at least 2 years) if possible. Calcifications identified on screening mammography that do not clearly appear benign should be recalled (BI-RADS 0).
At diagnostic mammography, additional views with magnification should be performed to confirm the morphology and number of calcifications.
Short interval followup
Other types of calcifications may be categorized as probably benign (BI-RADS 3) if the radiologist has personal experience justifying a watchful waiting approach, but these approaches are not supported by substantial evidence 7:
- developing calcifications that are most likely, but are not definitely, vascular
- calcifications suggestive of early evolving fat necrosis
For suspicious calcifications, a focused ultrasound is reasonable to evaluate for a mammographically occult abnormality such as a mass. Calcifications can sometimes be redemonstrated on ultrasound as well, providing another option for image-guided biopsy.
Core needle biopsy of suspicious calcifications should be performed (BI-RADS 4 or 5) with image guidance using the available modality that best demonstrated the findings, which often means stereotactic or digital breast tomosynthesis-guided biopsy 8. Specimen radiographs should be obtained to confirm adequate sampling of the calcifications. Especially in the case of ultrasound-guided or MRI-guided biopsy, a biopsy marker should be deposited so that the correct biopsy site can be confirmed on post-biopsy mammography.
If no calcifications are identified at histology, the entire paraffin block can be radiographed and further sections obtained if there are indeed calcifications present 9.
- 1. Sickles EA. Breast calcifications: mammographic evaluation. Radiology. 1986;160 (2): 289-93. Pubmed citation
- 2. Kuzmiak CM, Dancel R, Pisano E et-al. Consensus review: A method of assessment of calcifications that appropriately undergo a six-month follow-up. Acad Radiol. 2006;13 (5): 621-9. doi:10.1016/j.acra.2006.01.042 - Pubmed citation
- 3. Bassett LW. Mammographic analysis of calcifications. Radiol. Clin. North Am. 1992;30 (1): 93-105. Pubmed citation
- 4. Lanyi M. Diagnosis and Differential Diagnosis of Breast Calcifications. Springer. ISBN:3642714951. Read it at Google Books - Find it at Amazon
- 5. Wilkinson L, Thomas V, Sharma N. Microcalcification on mammography: approaches to interpretation and biopsy. (2017) The British journal of radiology. 90 (1069): 20160594. doi:10.1259/bjr.20160594 - Pubmed
- 6. D’Orsi CJ, Sickles EA, Mendelson EB, Morris EA, et al. ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System. Reston, VA, American College of Radiology; 2013. ISBN:155903016X. Read it at Google Books - Find it at Amazon
- 7. Michaels AY, Birdwell RL, Chung CS, Frost EP, Giess CS. Assessment and Management of Challenging BI-RADS Category 3 Mammographic Lesions. (2016) Radiographics : a review publication of the Radiological Society of North America, Inc. 36 (5): 1261-72. doi:10.1148/rg.2016150231 - Pubmed
- 8. Horvat JV, Keating DM, Rodrigues-Duarte H, Morris EA, Mango VL. Calcifications at Digital Breast Tomosynthesis: Imaging Features and Biopsy Techniques. (2019) Radiographics : a review publication of the Radiological Society of North America, Inc. 39 (2): 307-318. doi:10.1148/rg.2019180124 - Pubmed
- 9. Idowu MO, Hardy LB, Hardy LB, Souers RJ, Nakhleh RE. Pathologic diagnostic correlation with breast imaging findings: a College of American Pathologists Q-Probes study of 48 institutions. (2012) Archives of pathology & laboratory medicine. 136 (1): 53-60. doi:10.5858/arpa.2011-0217-CP - Pubmed