Brenner tumour

Brenner tumours are an uncommon surface epithelial tumour of the ovary. It was originally known as a transitional cell tumour due to its histological similarity to the urothelium. Brenner tumours account for ~3% of ovarian epithelial neoplasms. They can very rarely occur in other locations, including the testis.

Most often found incidentally in women between their 5th and 7th decades of life.

They are most frequently found incidentally on pelvic examination or at laparotomy.

Histological specimens often show transitional cells similar to neoplasms of the urothelium 8.

Associations

Brenner tumours are associated with another epithelial ovarian neoplasm of either the ipsilateral or contralateral ovary in ~30% of cases 6.  

Location 

Brenner tumours can be bilateral in 6-7% of cases.

Often manifest as a multilocular cystic mass with a solid component or as a mostly solid mass.

Tumours are usually small (<2 cm). Even with the occasional large tumour (>10 cm), there is often a lack of local invasion, lymphadenopathy, ascites, or metastases (i.e. peritoneal metastasesomental caking), which help distinguish it from other malignant ovarian neoplasms.

Pelvic ultrasound

Brenner tumours are similar to other solid ovarian neoplasms, particularly fibromas-thecomas, and can also be confused with pedunculated leiomyomas. 

They are mainly hypoechoic solid masses. Calcifications have been reported in 50% of Brenner tumours on ultrasound.

CT
  • calcifications have been reported in ~85% of Brenner tumours on CT
  • solid component may show mild to moderate enhancement post-contrast
MRI
  • due to its predominantly fibrous content content they appear hypointense on T2-weighted sequences

Most Brenner tumours are benign.

General imaging differential considerations include:

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Article information

rID: 12333
System: Gynaecology
Section: Pathology
Synonyms or Alternate Spellings:
  • Brenner tumor of ovary
  • Brenner tumor
  • Brenner tumour of ovary
  • Transitional cell tumour of the ovary
  • Ovarian transitional cell tumour

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