Brunner gland hyperplasia

Last revised by Dr Matt Adams on 07 Dec 2020

Brunner gland hyperplasia results from disproportionate overgrowth of Brunner glands in the duodenum as a result of hyperacidity.

Hyperplasia begins at the pylorus and extends distally within the first 2/3rds of the duodenum. Where the focal growth of hyperplastic cells is greater than 1 cm in diameter, the hyperplastic region is referred to as Brunner gland adenoma.

There are certain morphologic types:

  • diffuse nodular hyperplasia
  • circumscribed nodular hyperplasia (superpapillary portion)
  • single adenomatous hyperplastic polyp (duodenal bulb)

Radiographic features

  • multiple nodular filling defects (usually the 1st portion of duodenum)
  • cobblestoning
  • rarely, single large mass with central ulceration

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.