CA 19-9

Last revised by Dr Henry Knipe on 29 Sep 2021

CA 19-9 (carbohydrate antigen 19-9 or cancer antigen 19-9) is a serum antigen (monosialoganglioside) that has increased diagnostic use in the management of several malignancies, mainly of hepatopancreaticobiliary origin. It is non-specific, however, and can rise in both malignant and non-malignant conditions.

Elevated serum CA 19-9

Elevation of serum CA 19-9 has been associated with many conditions including the following:

History and etymology

It was initially discovered by H Koprowski and co-workers in 1980 associated with colon and pancreatic cancer 9.

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