Calcinosis universalis

Changed by Marcin Czarniecki on 29 Jun 08:14

Updates to Article Attributes

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Calcinosis universalis is a condition characterised by long bands or sheets of symmetrical subcutaneous calcification.

Clinical presentation

It usually presents <20 years of age, and is more common in women.

  • palpable calcific plaques in subcutaneous or deeper tissue
  • fatigue., muscle pain, and stiffness
  • possible high levels of γ-carboxyglutamic acid in tissues and urine

~1/3 of cases are associated with sclerodermadermatomyositis, polymyositis, and systemic lupus erythematosus.

Radiologic features

Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.

Treatment and prognosis

No established therapy is recognised, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.

Differential diagnosis

  • -<li>fatigue. muscle pain, and stiffness</li>
  • +<li>fatigue, muscle pain, and stiffness</li>

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Cases and figures

  • Case 1: possible dermatomyositis with calcinosis cutis
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  • Case 2
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  • Case 3
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