Calcinosis universalis
Updates to Article Attributes
Body
was changed:
Calcinosis universalis is a condition characterised by long bands or sheets of symmetrical subcutaneous calcification.
Clinical presentation
It usually presents <20 years of age, and is more common in women.
- palpable calcific plaques in subcutaneous or deeper tissue
- fatigue
., muscle pain, and stiffness - possible high levels of γ-carboxyglutamic acid in tissues and urine
~1/3 of cases are associated with scleroderma, dermatomyositis, polymyositis, and systemic lupus erythematosus.
Radiologic features
Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.
Treatment and prognosis
No established therapy is recognised, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.
Differential diagnosis
- fibrodysplasia ossificans progressiva
- myositis ossificans
- dermatopolymyositis
-<li>fatigue. muscle pain, and stiffness</li>- +<li>fatigue, muscle pain, and stiffness</li>