Calcinosis universalis

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Calcinosis universalis is a condition characterized by long bands or sheets of symmetrical subcutaneous calcification.

Clinical presentation

It usually presents <20 years of age, and is more common in women.

palpable calcific plaques in subcutaneous or deeper tissue
fatigue. muscle pain, and stiffness
possible high levels of γ-carboxyglutamic acid in tissues and urine

~1/3 of cases are associated with scleroderma, dermatomyositis, polymyositis, and systemic lupus erythematosus.

Radiologic features

Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.

Treatment and prognosis

No established therapy is recognized, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.

Differential diagnosis

-<p><strong>Calcinosis universalis</strong> is a condition characterized by long bands of symmetrical subcutaneous calcification.</p><h4>Clinical presentation</h4><p>It usually presents <20 years of age, and is more common in women.</p><ul>
+<p><strong>Calcinosis universalis</strong> is a condition characterized by long bands or sheets of symmetrical subcutaneous calcification.</p><h4>Clinical presentation</h4><p>It usually presents <20 years of age, and is more common in women.</p><ul>
-</ul><p>~1/3 of cases are associated with <a title="Scleroderma" href="/articles/scleroderma">scleroderma</a> or <a title="Dermatomyositis" href="/articles/dermatomyositis">dermatomyositis</a>.</p><h4>Radiologic features</h4><p>Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.</p><h4>Treatment and prognosis</h4><p>No established therapy is recognized, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.</p><h4>Differential diagnosis</h4><ul>
~~-<li><a title="Fibrodysplasia ossificans progressiva" href="/articles/fibrodysplasia-ossificans-progressiva">fibrodysplasia ossificans progressiva</a></li>~~
~~-<li><a title="Myositis Ossificans (MO)" href="/articles/myositis-ossificans-1">myositis ossificans</a></li>~~
+</ul><p>~1/3 of cases are associated with <a href="/articles/scleroderma">scleroderma</a>, <a href="/articles/dermatomyositis">dermatomyositis</a>, <a title="Polymyositis" href="/articles/polymyositis">polymyositis</a>, and <a title="Systemic lupus erythematosus (SLE)" href="/articles/systemic-lupus-erythematosus">systemic lupus erythematosus</a>.</p><h4>Radiologic features</h4><p>Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.</p><h4>Treatment and prognosis</h4><p>No established therapy is recognized, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.</p><h4>Differential diagnosis</h4><ul>
+<li><a href="/articles/fibrodysplasia-ossificans-progressiva">fibrodysplasia ossificans progressiva</a></li>
+<li><a href="/articles/myositis-ossificans-1">myositis ossificans</a></li>

References changed:

1. Santili C, Akkari M, Waisberg G et-al. Calcinosis universalis: a rare diagnosis. J Pediatr Orthop B. 2005;14 (4): 294-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15931036">Pubmed citation</a><span class="auto"></span>
2. Olsen KM, Chew FS. Tumoral calcinosis: pearls, polemics, and alternative possibilities. Radiographics. 2006;26 (3): 871-85. <a href="http://radiographics.rsna.org/content/26/3/871.full">Radiographics (full text)</a> - <a href="http://dx.doi.org/10.1148/rg.263055099">doi:10.1148/rg.263055099</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/16702460">Pubmed citation</a><span class="ref_v3"></span>

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