Calcium pyrophosphate dihydrate deposition disease
Calcium pyrophosphate dihydrate disease (CPPD disease), also known as pyrophosphate arthropathy or pseudogout, is defined by the co-occurrence of arthritis with evidence of CPPD deposition within the articular cartilage.
The terminology regarding CPPD disease has been confusing, with chondrocalcinosis, CPPD, and pseudogout often used synonymously. Indeed, although initially described as chondrocalcinosis articularis, it is now understood that imaging findings of chondrocalcinosis do not always indicate CPPD disease 9.
In response, in 2011 the European League Against Rheumatism (EULAR) proposed a standardized terminology corresponding to clinical presentation 9:
- CPPD - occurrence of calcium pyrophosphate crystals, with or without symptoms
- asymptomatic CPPD - chondrocalcinosis +/- changes of osteoarthritis, but clinically asymptomatic
- acute CPPD crystal arthritis (formerly pseudogout) - self-limiting synovitis in the setting of CPPD
- osteoarthritis with CPPD - typical changes of osteoarthritis in the setting of CPPD
- chronic CPPD crystal inflammatory arthritis
CPPD is commonest in patients over the age of 50. Men and women are equally affected.
Most patients with imaging findings of CPPD are clinically asymptomatic.
Acute CPPD crystal arthritis (pseudogout) presents with severe acute or subacute pain, swelling, erythema, and warmth, of one or more joints and is usually self-limited. The presentation classically resembles an acute gout attack. Unlike gout, it most commonly involves the knee and more commonly involves the upper joints (shoulder, elbow, wrist).
Chronic CPPD crystal inflammatory arthritis presents with chronic, intermittent painful swelling in the peripheral joints of upper and lower extremities.
The crystals are weakly positively birefringent on polarised microscopy and have a rhomboid or rod shape.
Causes of CPPD can be divided into:
- AD pattern; mutation in the ANKH gene which encodes a transmembrane inorganic pyrophosphate transporter
CPPD has many features of osteoarthritis with an unusual distribution, for example, they tend to be symmetric in distribution and involve non-weight bearing joints or, in the hands, mainly involve the intercarpal and MCP joints.
Features of degenerative joint disease in joints that are not commonly affected by it (i.e. non-weight bearing joints):
- wrist joint (mainly radiocarpal and scapholunate joints)
- patellofemoral joint
- shoulder joint
- elbow joint
Chondrocalcinosis can occur in many locations. Notable sites include:
- knee: medial meniscus and patellofemoral joint
- wrist: triangular fibrocartilage complex and lunotriquetral ligaments
- spine: periodontoid tissue
Large subchondral cysts may be present.
It is controversial whether gout leads to calcification of articular fibrocartilage or hyaline cartilage 6. CPPD disease can be differentiated from gout on ultrasound given that echogenic monosodium urate crystals line the surface of articular cartilage, whereas echogenic CPPD calcifications are located within the cartilage itself 7.
Possible imaging differential considerations include
- usually have the typical weight-bearing distribution
giant cell tumor (GCT)
- subchondral cysts of CPPD can be large and simulate subchondral GCT
- 1. Resnick D, Niwayama G, Goergen TG et-al. Clinical, radiographic and pathologic abnormalities in calcium pyrophosphate dihydrate deposition disease (CPPD): pseudogout. Radiology. 1977;122 (1): 1-15. doi:10.1148/122.1.1 - Pubmed citation
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- 4. Kaushik S, Erickson JK, Palmer WE et-al. Effect of chondrocalcinosis on the MR imaging of knee menisci. AJR Am J Roentgenol. 2001;177 (4): 905-9. AJR Am J Roentgenol (full text) - Pubmed citation
- 5. Scutellari PN, Galeotti R, Leprotti S et-al. The crowned dens syndrome. Evaluation with CT imaging. Radiol Med. 2007;112 (2): 195-207. doi:10.1007/s11547-007-0135-7 - Pubmed citation
- 6. Brower AC, USNR DJFMDCDRMC. Arthritis in Black and White. Saunders. ISBN:1416055959. Read it at Google Books - Find it at Amazon
- 7. Thiele RG, Schlesinger N. Diagnosis of gout by ultrasound. Rheumatology (Oxford). 2007;46 (7): 1116-21. doi:10.1093/rheumatology/kem058 - Pubmed citation
- 8. Saffar P. Chondrocalcinosis of the wrist. Journal of hand surgery (Edinburgh, Scotland). 29 (5): 486-93. doi:10.1016/j.jhsb.2004.02.013 - Pubmed
- 9. Zhang W, Doherty M, Bardin T, Barskova V, Guerne PA, Jansen TL, Leeb BF, Perez-Ruiz F, Pimentao J, Punzi L, Richette P, Sivera F, Uhlig T, Watt I, Pascual E. European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis. (2011) Annals of the rheumatic diseases. 70 (4): 563-70. doi:10.1136/ard.2010.139105 - Pubmed
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