Call-Fleming syndrome

Call-Fleming syndrome, also called Call syndrome, is a subset of reversible cerebral vasoconstriction syndrome. It is characterised by a history of thunderclap headache with subsequent beaded appearance of the circle of Willis on angiography (as seen in RCVS), but with no identifiable cause.

History and etymology

It was first described by Call and Fleming et al, in 1988 2 where they described 19 patients with "reversible cerebral arterial segmental vasoconstriction", who presented with thunderclap headaches with or without focal neurology, without evidence of subarachnoid haemorrhage (SAH). A number of predisposing factors have since been found to contribute to what is now described as RCVS. However, idiopathic cases of RCVS still exist and are now named Call-Fleming.

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Article information

rID: 4527
Synonyms or Alternate Spellings:
  • Call syndrome
  • Call Fleming syndrome

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Cases and figures

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