Callen MS-ADEM criteria
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At the time the article was created Marcos Gil Alberto da Veiga had no recorded disclosures.View Marcos Gil Alberto da Veiga's current disclosures
At the time the article was last revised Patrick J Rock had no recorded disclosures.View Patrick J Rock's current disclosures
The Callen MS-ADEM criteria can be useful in differentiating between acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in children, as the first attack of immune-mediated demyelination is a frequent diagnostic challenge.
Given the diagnostic challenge, several diagnostic criteria may be used to differentiate, e.g. Barkhof criteria, KIDMUS criteria, Callen MS-ADEM criteria, Callen diagnostic MS criteria. A 2010 study compared these different criteria, with the Callen MS-ADEM criteria 1 showing the best combination of sensitivity (75%) and specificity (95%) 2.
The proposed criteria can only be applied to distinguish children with the clinical presentation of ADEM from that of a first MS attack.
At least two out of the three following criteria should be fulfilled for MS diagnosis:
- absence of a diffuse bilateral lesion pattern
- presence of black holes
- two periventricular lesions