Callen MS-ADEM criteria
Citation, DOI, disclosures and article data
At the time the article was created Marcos Gil Alberto da Veiga had no recorded disclosures.
View Marcos Gil Alberto da Veiga's current disclosuresAt the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosures- Callen criteria
The Callen MS-ADEM criteria can be useful in differentiating between acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in children, as the first attack of immune-mediated demyelination is a frequent diagnostic challenge.
Usage
The Callen MS-ADEM criteria compare well against several other diagnostic criteria (e.g. KIDMUS criteria, IPMSSG criteria) and perform better than others (e.g. Barkhof criteria, McDonald 2017, MAGMINS) 2,3.
Criteria
The criteria can only be applied to distinguish children with the clinical presentation of ADEM from that of a first MS attack. At least two out of the three following criteria should be fulfilled for MS diagnosis 1:
absence of a diffuse bilateral lesion pattern
presence of black holes
two periventricular lesions
References
- 1. Callen D, Shroff M, Branson H et al. Role of MRI in the Differentiation of ADEM from MS in Children. Neurology. 2009;72(11):968-73. doi:10.1212/01.wnl.0000338630.20412.45 - Pubmed
- 2. Ketelslegers I, Neuteboom R, Boon M, Catsman-Berrevoets C, Hintzen R, Hintzen R. A Comparison of MRI Criteria for Diagnosing Pediatric ADEM and MS. Neurology. 2010;74(18):1412-5. doi:10.1212/WNL.0b013e3181dc138b - Pubmed
- 3. Boesen M, Blinkenberg M, Thygesen L, Ilginiene J, Langkilde A. Magnetic Resonance Imaging Criteria at Onset to Differentiate Pediatric Multiple Sclerosis from Acute Disseminated Encephalomyelitis: A Nationwide Cohort Study. Mult Scler Relat Disord. 2022;62:103738. doi:10.1016/j.msard.2022.103738 - Pubmed
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