Callososeptal interface

Last revised by Daniel J Bell on 25 May 2018

The callososeptal interface is located on the inferior surface of the corpus callosum, where the septum pellucidum abuts it. 

It came to radiological attention when T2 hyperintense lesions affecting this region were believed to be specific for multiple sclerosis. This has, as is usually the case, been shown not to be quite as cut and dry, with ischemic lesions also potentially affecting this region 1.

Practical points

Involvement of the callososeptal interface may help in distinguishing multiple sclerosis from Susac syndrome as the latter predominantly involves the central part of the corpus callosum rather than the interface 2.

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Cases and figures

  • Figure 1: arrows demonstrate the interface
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  • Case 1: multiple sclerosis
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