Last revised by Joachim Feger on 11 Dec 2021

Calponin is an actin-binding protein regulating actin/myosin interaction in smooth muscle and non-muscle cells 1,2. It inhibits actin-activated myosin ATPase and stabilizes the actin cytoskeleton. It also serves as a target in immunohistochemistry where it can be used for the identification of myoepithelial cells or the characterization of tumors.

Immunohistochemistry stains might be positive in the following lesions:

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