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Calponin is an actin-binding protein regulating actin/myosin interaction in smooth muscle and non-muscle cells 1,2. It inhibits actin-activated myosin ATPase and stabilizes the actin cytoskeleton. It also serves as a target in immunohistochemistry where it can be used for the identification of myoepithelial cells or the characterization of tumors.
Immunohistochemistry stains might be positive in the following lesions:
- 1. Liu R & Jin J. Calponin Isoforms CNN 1, CNN 2 and CNN 3: Regulators for Actin Cytoskeleton Functions in Smooth Muscle and Non-Muscle Cells. Gene. 2016;585(1):143-53. doi:10.1016/j.gene.2016.02.040 - Pubmed
- 2. Ferjani I, Fattoum A, Manai M, Benyamin Y, Roustan C, Maciver S. Two Distinct Regions of Calponin Share Common Binding Sites on Actin Resulting in Different Modes of Calponin-Actin Interaction. Biochim Biophys Acta. 2010;1804(9):1760-7. doi:10.1016/j.bbapap.2010.05.012 - Pubmed