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Citation:
Bell D, Carcinoma of the Littré glands. Reference article, Radiopaedia.org (Accessed on 28 Mar 2023) https://doi.org/10.53347/rID-93195
Carcinoma of the Littré glands is rare. The Littré (urethral) glands of the penis may be the origin of cancers of the penis, usually adenocarcinomas 1.
There are only a few scattered case reports of true Littré gland malignancy, although it is probably under-reported due to the fact that some penile adenocarcinomas arise from the Littre glands but are described in disease registries as penile malignancies 1-5.
Similar to penile carcinoma.
Penile adenocarcinomas arise from the Littré or bulbourethral (Cowper) glands.
The imaging appearances of carcinoma of the Littré glands may mimic inflammatory disease 5.
- 1. Kawashima A, Sandler C, Wasserman N, LeRoy A, King B, Goldman S. Imaging of Urethral Disease: A Pictorial Review. Radiographics. 2004;24(suppl_1):S195-S216. doi:10.1148/rg.24si045504
- 2. Raspollini M, Carini M, Montironi R, Cheng L, Lopez-Beltran A. Mucinous Adenocarcinoma of the Male Urethra: A Report of Two Cases. Anal Quant Cytopathol Histpathol. 2015;37(4):267-72. PMID 26410973
- 3. Dobos E, Downing S, Ashe S. Primary Carcinoma Originating in the Littre Glands. Cancer. 1954;7(3):539-48. doi:10.1002/1097-0142(195405)7:3<539::aid-cncr2820070313>3.0.co;2-7
- 4. Costa M, Sugita D, Vilela M et al. Mucoepidermoid Carcinoma of the Penis: Case Report and Literature Review. Can Urol Assoc J. 2015;9(1-2):E27-9. doi:10.5489/cuaj.2126
- 5. Krawitt L & Schechterman L. Inflammation of the Periurethral Glands of Littre Simulating Tumor. J Urol. 1977;118(4):685. doi:10.1016/s0022-5347(17)58157-4
- 6. Germinale T. [A Case of Adenocarcinoma of the Anterior Part of the Male Urethra Probably Originating from the Littré's Glands]. Pathologica. 1954;46(719-720):195-201. PMID 14394696
- 7. Starzyński S & Litwak A. [Cancer of the Urethra Originating from Littré's Glands]. Patol Pol. 1965;16(2):235-41. PMID 5834350
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