Cardiac sclerosis

Dr Henry Knipe et al.

Cardiac sclerosis, or "cardiac cirrhosis" is the end-point of passive hepatic congestion from heart failure

Aetiology

Causes of cardiac cirrhosis include 1:

  • ischaemic heart disease: ~30%
  • cardiomyopathy: ~25%
  • valvular heart disease: ~25%
  • restrictive lung disease: ~15%
  • pericardial disease: ~10%
Pathophysiology

Fibrosis bridging between central zonal regions can occur if passive hepatic congestion persists for a long time. This process is best termed cardiac sclerosis, as unlike in cirrhosis due to noxious or viral insults, there is minimal nodular regeneration.

Features are those of cirrhosis, identical to other causes 3

Cardiac cirrhosis may be irreversible even after treatment of the underlying cardiac failure 2

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Article Information

rID: 42149
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Cardiac cirrhosis

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