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Citation:
Sharma R, Cascade sign (Behçet disease). Reference article, Radiopaedia.org (Accessed on 06 Dec 2024) https://doi.org/10.53347/rID-183987
The cascade sign, also known as the waterfall sign, is a radiological sign appreciated on MRI brain that is described in patients with neuro-Behçet disease involving the mesodiencephalic junction.
The sign describes the involvement of the mesodiencephalic junction as seen on coronal T2/FLAIR sequences, whereby there is high signal that extends from the thalamus and/or internal capsule caudally to the ipsilateral midbrain 1-3. This region of high signal often has ill-defined margins and overall, has a shape which resembles a cascade or waterfall 1-3.
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1. Cleaver J, Morrison H, Renowden S, Atan D, Cossburn M, Rice C. An Important Diagnostic Clue for Neuro-Behçet’s Disease: The ‘cascade Sign’. Rheumatology. 2021;61(5):e130-1. doi:10.1093/rheumatology/keab554 - Pubmed
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2. Pretorius J, Hiesgen J, Myburgh M, Suleman F. Neuro-Behçet - Clinical and Radiological Findings in a Patient of Sub-Saharan African Origin. Radiol Case Rep. 2022;17(3):592-8. doi:10.1016/j.radcr.2021.11.046 - Pubmed
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3. Mahale R, Kamath S, Ravindranadh C, Padmanabha H, Mailankody P, Pavagada M. Neuro-Bechet’s Disease: A Case Series from India. Egypt J Neurol Psychiatry Neurosurg. 2022;58(1):1-7. doi:10.1186/s41983-022-00586-3
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