CD34

CD34 or hematopoietic progenitor cell antigen CD34 is an intercellular adhesion protein and cell surface glycoprotein and a frequently used marker of hematopoietic progenitor cells and endothelial cells. It is also expressed by many other non-hematopoietic cell types including multipotent mesenchymal stromal cells, interstitial dendritic cells and epithelial progenitors ¹.

Usage

It serves as a target in immunohistochemistry where it can be used for the determination of vascularization of tumors and disease processes and the differentiation of different tumors as:

• Kaposi sarcoma, dermatofibrosarcoma protuberans vs cutaneous fibrous histiocytoma
• solitary fibrous tumor vs desmoplastic mesothelioma
• confirmation of gastrointestinal stromal tumors