Ceftriaxone-associated gallbladder pseudolithiasis
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At the time the article was created Henry Knipe had no recorded disclosures.View Henry Knipe's current disclosures
At the time the article was last revised Yaïr Glick had no recorded disclosures.View Yaïr Glick's current disclosures
Ceftriaxone-associated gallbladder pseudolithiasis is a not-uncommon complication of this common antibiotic, where a ceftriaxone-calcium precipitate forms gallbladder sludge. It appears more common in pediatric patients.
In one series, 25% of pediatric patients developed gallbladder pseudolithiasis whilst receiving ceftriaxone 1.
Approximately 40% of ceftriaxone is excreted into the biliary system, and ceftriaxone can concentrate in the gallbladder and can precipitate with calcium, resulting in the formation of a ceftriaxone-calcium complex 2,3.
Sludge appearing as a hyperechoic layer, without posterior acoustic shadowing 2.
Treatment and prognosis
This phenomenon may be fully reversible, taking between 2 and 63 days to resolve post cessation of treatment 2. Ceftriaxone can be a cause of gallstone formation.
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- 2. Choi YY, Jung YH, Choi SM, Lee CS, Kim D, Hur KY. Gallbladder pseudolithiasis caused by ceftriaxone in young adult. (2011) Journal of the Korean Surgical Society. 81 (6): 423-6. doi:10.4174/jkss.2011.81.6.423 - Pubmed
- 3. Aditi Nayak, Adam Slivka. Ceftriaxone-Induced Gallstones: Case Report and Literature Review. (2014) ACG Case Reports Journal. 1 (3): 170. doi:10.14309/crj.2014.40 - Pubmed