Cellular nonspecific interstitial pneumonitis
Cellular nonspecific interstitial pneumonia is one of the two histological subtypes of non specific interstitial pneumonia (NSIP). It is less common compared with fibrotic NSIP but carries a much better prognosis.
Symptoms are non-specific and include insidious onset of dyspnea and dry cough with restrictive pattern of decreased lung function and reduced gas exchange capacity.
This pattern manifests as mild to moderate chronic interstitial inflammation and type II pneumocyte hyperplasia, with preservation of the lung architecture.
Absence of hyaline membranes and other findings of acute lung injury, granulomas, organisms or viral inclusions, dominant airways disease, eosinophils, dense interstitial fibrosis, diffuse severe alveolar septal inflammation, and organizing pneumonia involves <20% of the biopsy specimen are considered important negative findings help to distinguish NSIP from other interstitial lung diseases.
Chest radiographs can be normal in early stages. There may be ill-defined or ground glass opacities with lower lobe distribution or consolidation in a patchy, reticulonodular or mixed pattern.
Imaging features can overlap between cellular and fibrotic types as well as usual interstitial pneumonia (UIP) in as many as 30% of patients. Also temporal changes in the pattern of HRCT findings in subsequent studies are shown in up to 28% of cases, which result in changes of the provisional diagnosis from NSIP to UIP.
Involvement tends to be sub-pleural and generally symmetrical with apicobasilar gradient. Solely or predominantly upper lobe involvement or purely unilateral disease makes the diagnosis of NSIP less likely.
Common manifestations include:
- ground-glass opacities
- tends to be a dominant feature: can be symmetrically or diffusely distributed in all zones or display a basal predominance
- immediate subpleural sparing: relatively specific sign
- fine reticular opacities
Following imaging features are more common in fibrotic type:
- thickening of bronchovascular bundles
- traction bronchiectasis: associated with fibrotic NSIP
- lung volume loss: particularly lower lobes
Treatment and prognosis
Cellular type usually responding very well to the corticosteroids with almost 100% 10 year survival.
Interstitial lung disease
interstitial lung disease
- drug-induced interstitial lung disease
- hypersensitivity pneumonitis
idiopathic interstitial pneumonia (mnemonic)
- acute interstitial pneumonia (AIP)
- cryptogenic organising pneumonia (COP)
- desquamative interstitial pneumonia (DIP)
- idiopathic nonspecific interstitial pneumonia (NSIP)
- idiopathic pleuroparenchymal fibroelastosis
- lymphoid interstitial pneumonia (LIP)
- respiratory bronchiolitis–associated interstitial lung disease (RB-ILD)
- usual interstitial pneumonia / idiopathic pulmonary fibrosis (UIP/IPF)
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