Centrilobular lung nodules
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Centrilobular lung nodules refer to an HRCT chest imaging descriptor for lung nodules which are anatomically located centrally within secondary pulmonary lobules. The term is applied on the basis of position of the nodule and not it'sits morphology. Centrilobular nodules can therefore - they may be well defined or poorly defined.
Pathology
Aetiology
Centrilobular nodules can be observed in a wide variety of lung pathology.
They They are usually seen with a bronchiolitis (i.e with bronchiolar or peri-bronchiolar abnormalities).
Specific Specific conditions include:
- bronchiolitides
- infection with endobronchial spread
- airway spread of tuberculosis
- airway spread of non tuberculous mycobacterial infection
- airway invasive aspergillosis 3
- bronchoalveolar carcinoma with airway spread
-
subacute
hypersensitivityhypersensitivity pneumonitis1 -
bronchiolitides - respiratory bronchiolitis interstitial lung disease (RB-ILD) 5
- pulmonary vasculitides
When centrilobular nodules are interspersed with linear and branching densities, it is then termed a tree-in-bud pattern.
Radiographic features
HRCT chest
Centrilobular nodules are typically around the small airways and spare the subpleural surfaces. They are typically at least 5-10 mm away from the pleural surfaces ref.
See also
-<p><strong>Centrilobular lung nodules </strong>refer to an HRCT chest imaging descriptor for lung nodules which are anatomically located centrally within secondary pulmonary lobules. The term is applied on the basis of position of the nodule and not it's morphology. Centrilobular nodules can therefore well defined or poorly defined.</p><p>Centrilobular nodules can be observed in a wide variety of lung pathology. </p><p>They are usually seen with a <a href="/articles/bronchiolitis">bronchiolitis</a> (i.e with bronchiolar or peri-bronchiolar abnormalities).</p><p>Specific conditions include:</p><ul>-<li>infection with endobronchial spread<ul>-<li>airway spread of <a href="/articles/tuberculosis">tuberculosis </a>- +<p><strong>Centrilobular lung nodules </strong>refer to an <a title="HRCT chest" href="/articles/hrct-chest">HRCT chest</a> imaging descriptor for lung nodules which are anatomically located centrally within <a title="Secondary pulmonary lobules" href="/articles/secondary-pulmonary-lobule">secondary pulmonary lobules</a>. The term is applied on the basis of position of the nodule and not its morphology - they may be well defined or poorly defined.</p><h4>Pathology</h4><h5>Aetiology</h5><p>Centrilobular nodules can be observed in a wide variety of lung pathology. They are usually seen with a <a href="/articles/bronchiolitis">bronchiolitis</a> (i.e with bronchiolar or peri-bronchiolar abnormalities). Specific conditions include:</p><ul>
- +<li>
- +<a href="/articles/bronchiolitides">bronchiolitides</a><ul><li>
- +<a href="/articles/obliterative-bronchiolitis">obliterative bronchiolitis</a> <sup>3</sup>
- +</li></ul>
-<li>airway spread of <a href="/articles/pulmonary-non-tuberculous-mycobacterial-infection-2">non tuberculous mycobacterial infection</a>- +<li>infection with endobronchial spread<ul>
- +<li>airway spread of <a href="/articles/tuberculosis">tuberculosis</a> </li>
- +<li>airway spread of <a href="/articles/pulmonary-non-tuberculous-mycobacterial-infection-3">non tuberculous mycobacterial infection</a>
-<a href="/articles/adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma-in-lung">bronchoalveolar carcinoma</a> with airway spread</li>- +<a href="/articles/adenocarcinoma-in-situ-minimally-invasive-adenocarcinoma-and-invasive-adenocarcinoma-of-lung">bronchoalveolar carcinoma</a> with airway spread</li>
-<a href="/articles/sub-acute-hypersensitivity-pneumonitis">subacute hypersensitivity pneumonitis </a><sup>1</sup> </li>-<li>-<a href="/articles/bronchiolitides">bronchiolitides</a><ul><li>-<a href="/articles/obliterative-bronchiolitis">obliterative bronchiolitis</a> <sup>3</sup>-</li></ul>-</li>- +<a href="/articles/sub-acute-hypersensitivity-pneumonitis">subacute hypersensitivity pneumonitis </a><sup>1</sup> </li>
-<a href="/articles/respiratory-bronchiolitis-interstitial-lung-disease-1">respiratory bronchiolitis interstitial lung disease</a> <sup>5</sup>- +<a href="/articles/respiratory-bronchiolitis-interstitial-lung-disease-1">respiratory bronchiolitis interstitial lung disease</a> (RB-ILD) <sup>5</sup>
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