Centrilobular lung nodules

Changed by Yuranga Weerakkody, 14 Feb 2013
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Centrilobular lung nodules refer to an HRCT - chest CT imaging descriptor for lung nodules which are anatomically located centrally within secondary pulmonary lobules. The term is applied on the basis of position of the nodule and not it's morphology. Centrilobular nodules can therefore well defined or poorly defined.

Centrilobular nodules can be observed in a wide variety of lung pathology. 

They are usually seen with a bronchiolitis (i.e with bronchiolar or peri-bronchiolar abnormalities).

Specific conditions include

When centrilobular nodules are interspersed with linear and branching densities, it is then termed a tree-in-bud pattern. 

Radiographic features

HRCT chest

Centrilobular nodules are typically around the small airways and spare the subpleural surfaces. They are typically at least 5-10mm away from the pleural surfaces ref.

See also

  • -<p><strong>Centrilobular lung nodules </strong>refer to an HRCT - chest CT imaging descriptor for lung nodules which are anatomically located centrally within secondary pulmonary lobules. The term is applied on the basis of position of the nodule and not it's morphology. Centrilobular nodules can therefore well defined or poorly defined.</p>
  • -<p>Centrilobular nodules can be observed in a wide variety of lung pathology. </p>
  • -<p>They are usually seen with a <a title="bronchiolitis" href="/articles/bronchiolitis">bronchiolitis</a> (i.e with bronchiolar or peri-bronchiolar abnormalities).</p>
  • -<p>Specific conditions include</p>
  • -<ul>
  • -<li>infection with endobronchial spread
  • -<ul>
  • -<li>airway spread of <a title="Tuberculosis" href="/articles/tuberculosis">tuberculosis </a> </li>
  • -<li>airway spread of <a title="Non tuberculous mycobacterial infection" href="/articles/non-tuberculous-mycobacterial-infection">non tuberculous mycobacterial infection</a> </li>
  • -<li>
  • -<a title="airway invasive aspergillosis" href="/articles/airway-invasive-aspergillosis">airway invasive aspergillosis</a> <sup>3</sup>
  • -</li>
  • +<p><strong>Centrilobular lung nodules </strong>refer to an HRCT - chest CT imaging descriptor for lung nodules which are anatomically located centrally within secondary pulmonary lobules. The term is applied on the basis of position of the nodule and not it's morphology. Centrilobular nodules can therefore well defined or poorly defined.</p><p>Centrilobular nodules can be observed in a wide variety of lung pathology. </p><p>They are usually seen with a <a href="/articles/bronchiolitis">bronchiolitis</a> (i.e with bronchiolar or peri-bronchiolar abnormalities).</p><p>Specific conditions include</p><ul>
  • +<li>infection with endobronchial spread<ul>
  • +<li>airway spread of <a href="/articles/tuberculosis">tuberculosis </a>
  • +</li>
  • +<li>airway spread of <a href="/articles/pulmonary-non-tuberculous-mycobacterial-infection-2">non tuberculous mycobacterial infection</a>
  • +</li>
  • +<li>
  • +<a href="/articles/airway-invasive-aspergillosis">airway invasive aspergillosis</a> <sup>3</sup>
  • +</li>
  • -</li>
  • -<li>
  • -<a title="Bronchoalveolar carcinoma" href="/articles/adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma-in-lung">bronchoalveolar carcinoma</a> with airway spread</li>
  • -<li>
  • -<a title="sub acute hypersensitivity pneumonitis " href="/articles/sub-acute-hypersensitivity-pneumonitis">sub acute hypersensitivity pneumonitis </a><sup>1</sup>  </li>
  • -<li>
  • -<a title="bronchiolitides" href="/articles/bronchiolitides">bronchiolitides</a>
  • -<ul><li>
  • -<a title="Obliterative bronchiolitis" href="/articles/obliterative-bronchiolitis">obliterative bronchiolitis</a> <sup>3</sup>
  • +</li>
  • +<li>
  • +<a href="/articles/adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma-in-lung">bronchoalveolar carcinoma</a> with airway spread</li>
  • +<li>
  • +<a href="/articles/sub-acute-hypersensitivity-pneumonitis">sub acute hypersensitivity pneumonitis </a><sup>1</sup>  </li>
  • +<li>
  • +<a href="/articles/bronchiolitides">bronchiolitides</a><ul><li>
  • +<a href="/articles/obliterative-bronchiolitis">obliterative bronchiolitis</a> <sup>3</sup>
  • -</li>
  • -<li>
  • -<a title="Respiratory bronchiolitis interstitial lung disease" href="/articles/respiratory-bronchiolitis-interstitial-lung-disease-1">respiratory bronchiolitis interstitial lung disease</a> <sup>5</sup>
  • -</li>
  • -<li>
  • -<a title="Pulmonary vasculitides" href="/articles/pulmonary-vasculitis">pulmonary vasculitides</a>
  • -<ul><li>
  • -<a title="Churg Strauss syndrome" href="/articles/churg-strauss-syndrome">Churg Strauss syndrome</a> <sup>4</sup>
  • +</li>
  • +<li>
  • +<a href="/articles/respiratory-bronchiolitis-interstitial-lung-disease-1">respiratory bronchiolitis interstitial lung disease</a> <sup>5</sup>
  • +</li>
  • +<li>
  • +<a href="/articles/pulmonary-vasculitis">pulmonary vasculitides</a><ul><li>
  • +<a href="/articles/eosinophilic-granulomatosis-with-polyangiitis">Churg Strauss syndrome</a> <sup>4</sup>
  • -</li>
  • -</ul><p>When centrilobular nodules are interspersed with linear and branching densities, it is then termed a <a title="Tree-in-bud pattern" href="/articles/tree-in-bud-sign-3">tree-in-bud pattern</a>. </p>
  • -<h4>Radiographic features</h4>
  • -<h5>HRCT chest</h5>
  • -<p>Centrilobular nodules are typically around the small airways and spare the subpleural surfaces. They are typically at least 5-10mm away from the pleural surfaces <sup>ref</sup>.</p>
  • -<h4>See also</h4>
  • -<ul>
  • -<li><a title="Lung nodules" href="/articles/pulmonary-nodule-1">lung nodules</a></li>
  • -<ul>
  • -<li><a title="Ground glass nodules" href="/articles/ground-glass-density-nodule">ground glass nodules</a></li>
  • -<li><a title="Calcified lung nodules" href="/articles/calcified-pulmonary-nodules">calcified lung nodules</a></li>
  • -<li><a title="perilymphatic nodules" href="/articles/perilymphatic-lung-nodules">perilymphatic nodules</a></li>
  • +</li>
  • +</ul><p>When centrilobular nodules are interspersed with linear and branching densities, it is then termed a <a href="/articles/tree-in-bud-sign-3">tree-in-bud pattern</a>. </p><h4>Radiographic features</h4><h5>HRCT chest</h5><p>Centrilobular nodules are typically around the small airways and spare the subpleural surfaces. They are typically at least 5-10mm away from the pleural surfaces <sup>ref</sup>.</p><h4>See also</h4><ul>
  • +<li>
  • +<a href="/articles/pulmonary-nodule-1">lung nodules</a><ul>
  • +<li><a href="/articles/ground-glass-density-nodule">ground glass nodules</a></li>
  • +<li><a href="/articles/calcified-pulmonary-nodules">calcified lung nodules</a></li>
  • +<li>
  • +<a href="/articles/perilymphatic-lung-nodules">perilymphatic nodules</a><ul><li><a title="Perifissural pulmonary nodules" href="/articles/perifissural-lung-nodules">perifissural pulmonary nodules</a></li></ul>
  • +</li>
  • -<li><a title="Secondary pulmonary lobule" href="/articles/secondary-pulmonary-lobule">secondary pulmonary lobule</a></li>
  • +</li>
  • +<li><a href="/articles/secondary-pulmonary-lobule">secondary pulmonary lobule</a></li>
Images Changes:

Image 3 CT (lung window) ( update )

Caption was changed:
Case 1 -: with tree in bud - Tb with endobronchial spread

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