Cerebellar liponeurocytoma

Cerebellar liponeurocytomas, also known as neurolipocytomas, are rare tumours of the cerebellum with neurocytic differentiation and abundant accumulation of intracellular lipid. They are considered WHO grade II tumours 1

As only a small number of cases have been reported, detailed epidemiological data is not available. Having said that, these tumours seem to be encountered in adults, typically in middle age and do not have a gender predilection 1

Clinical presentation is non-specific, relating to raised intracranial pressure (e.g. headache) and cerebellar signs (e.g. ataxia) 1

Cerebellar liponeurocytomas typically arise in the cerebellar hemispheres. 

They are considered WHO grade II tumour in the current (2016) WHO classification of CNS tumours 1

These tumours are composed of small neurocytic cells and lipoma-like lipid-laden cells which represent neuroepithelial cells with abundant cytoplasmic lipid 1

Cerebellar liponeurocytomas appear, as heterogeneous masses with fatty components, usually located laterally in the cerebellar hemispheres 1. Heterogeneous contrast enhancement is usually present 1

Due to low numbers, optimum management has yet to be determined. Surgical resection alone can effect a cure in some patients, although overall the 5-year-survivial is only approximately 50% 1

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Article information

rID: 52255
Synonyms or Alternate Spellings:
  • Neurolipocytomas
  • Lipomatous glioneurocytoma
  • Lipidized mature neuroectodermal tumour of the cerebellum

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