Cerebral amyloid deposition diseases are a group of related conditions characterised by the accumulation of cerebral amyloid-β (Aβ) in various parts of the central nervous system. They lead to inflammation, neurotoxicity, and vascular friability, and are typically encountered in the elderly.
Four main conditions are recognized and these are discussed separately 1:
Alzheimer disease (most common)
cerebral amyloid angiopathy (common)
cerebral amyloid angiopathy related inflammation (rare)
cerebral amyloidoma (very rare)
- 1. Miller-Thomas MM, Sipe AL, Benzinger TL et-al. Multimodality Review of Amyloid-related Diseases of the Central Nervous System. Radiographics. 2016;36 (4): 1147-63. doi:10.1148/rg.2016150172 - Pubmed citation