Cerebral fat embolism
Citation, DOI and article data
Cerebral fat embolism is one manifestation of fat embolism syndrome (FES).
Cerebral fat embolism typically occurs in patients with bony fractures (usually long bones of the lower limb). FES has an incidence of 1-3% following long bone fractures and 33% in patients with bilateral long bone fractures 18.
Rarely it has been described as part of a sickle cell crisis with bone marrow fat necrosis and subsequent embolism 4.
Cerebral manifestations of fat embolism syndrome can be highly variable and non-specific: the symptoms spectrum includes headache, lethargy, irritability, delirium, stupor, convulsions, or coma. Most cases can occur as subclinical events. Concurrent pulmonary or cutaneous features may aid in diagnosis.
Fat emboli usually reach the brain through either right-to-left cardiac shunt or through intact pulmonary circulation in those without a shunt 3.
The CT of the brain is normal in most cases 8. There may be evidence of diffuse edema with scattered low-attenuating areas and hemorrhage in some situations.
The distribution of changes in the brain is bilaterally symmetric and predominantly in the subcortical and deep white matter, including subcortical U-fibers, corpus callosum, and internal capsule. SWI and DWI are the most sensitive sequences 17. The distribution and pattern are variable and depends on how extensive embolization is, but often has an external watershed distribution (similar to other microembolisms).
- early (most common at 1-4 days): scattered punctate foci of cytotoxic edema (starfield pattern) 17
- later (most common at 5-14 days): confluent areas of cytotoxic edema in the white matter 17
- SWI: profuse microhemorrhages in the white matter (walnut kernel pattern) 12,13,16,17
- T2/FLAIR: may show small areas of high signal intensity indicating vasogenic edema
- T1: corresponding focal regions may show low T1 signal 9
- T1 C+: some of the areas of vasogenic may enhance 17
Classification of MRI features
These patterns have been divided into three main types based on chronicity, although the classification system has not been widely adopted in clinical practice 17.
- acute (type 1): scattered cytotoxic edema
- subacute (type 2)
- type 2A: confluent cytotoxic edema in white matter
- type 2B: vasogenic edema lesions that may enhance
- type 2C: petechial hemorrhages in white matter,
- chronic (type 3): cerebral atrophy change, persistent gliosis
The imaging differential to consider includes many other causes of multiple small foci of infarction or hemorrhage, although generally, only fat emboli will result in a very large number of tiny lesions on both SWI and DWI. Other diagnoses to consider 6:
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