Cerebral intraparenchymal hyperattenuation post thrombectomy
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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
At the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
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Cerebral intraparenchymal hyperattenuations have been increasingly recognized on CT scans following mechanical thrombectomy for treatment of thromboembolic ischemic stroke. It is a term that encompasses both contrast staining and petechial hemorrhagic change, and is used as distinguishing between the two is not always easy.
The distribution of cerebral intraparenchymal hyperattenuation correlates with the eventual volume of infarction – in other words, the pre-procedural infarct core plus any portions of penumbra which despite treatment will go on to infarct 1.
As such, intraparenchymal hyperattenuations immediately following mechanical thrombectomy, observed either on conventional multi-detector CT or flat-panel CT, can provide prognostic information as to the eventual volume of infarction 1.
Distinguishing between contrast staining and petechial hemorrhagic transformation is not easy, particularly when obtained on current flat-panel CT.
Contrast staining typically appears as areas of hyperdensity mostly confined to grey matter (cortex and deep grey matter) and represent areas of blood-brain barrier breakdown secondary to ischemia with microvascular extravasation of contrast into the extracellular space 1. Typically such staining clears within the first 19-24 hours after the procedure 2.
Dual-energy CT is also able to distinguish hyperdensity due to contrast versus hyperdensity due to hemorrhage 3.
Petechial hemorrhagic transformation
Petechial hemorrhagic transformation of an ischemic infarct (as opposed to macroscopic solid cerebral hemorrhages also sometimes encountered) can have a very similar appearance. Follow-up CT performed at least 19-24 hours following intervention is the most specific way to differentiate, with persistent hyperdensity consistent with hemorrhage whereas contrast staining will reduce in density over time 2.
- 1. Schneider T, Mahraun T, Schroeder J et al. Intraparenchymal Hyperattenuations on Flat-Panel CT Directly After Mechanical Thrombectomy Are Restricted to the Initial Infarct Core on Diffusion-Weighted Imaging. Clin Neuroradiol. 2018;28(1):91-7. doi:10.1007/s00062-016-0543-y - Pubmed
- 2. Dekeyzer S, Nikoubashman O, Lutin B et al. Distinction Between Contrast Staining and Hemorrhage After Endovascular Stroke Treatment: One CT is Not Enough. J Neurointerv Surg. 2017;9(4):394-8. doi:10.1136/neurintsurg-2016-012290 - Pubmed
- 3. Phan C, Yoo A, Hirsch J, Nogueira R, Gupta R. Differentiation of Hemorrhage from Iodinated Contrast in Different Intracranial Compartments Using Dual-Energy Head CT. AJNR Am J Neuroradiol. 2012;33(6):1088-94. doi:10.3174/ajnr.A2909 - Pubmed