Citation, DOI & article data
Chemical ablation is a technique in which chemical ablative substances are used to cause cell death in neoplastic tissue. It is used as a standalone procedure or in combination with other techniques like TACE and radiofrequency ablation.
- Absolute ethanol (most commonly used)
- Acetic acid
Mechanism of action
- Cytotoxic: Chemical substances causes cell death by means of cell membrane damage, protein denaturation and cellular dehydration.
- Vascular: agents also cause vascular endothelial damage and thrombosis 2.
- Hematoma : parenchymal and subcapsular hematoma formation
- Intestinal perforation
- Hepatic vein thrombosis
- Portal vein thrombosis
- Pneumothorax and pleural effusion
- Hepatic infarct
- Tumor seeding along the needle track
- 1.Filippiadis D, Mauri G, Marra P, Charalampopoulos G, Gennaro N, De Cobelli F. Percutaneous Ablation Techniques for Renal Cell Carcinoma: Current Status and Future Trends. Int J Hyperthermia. 2019;36(2):21-30. doi:10.1080/02656736.2019.1647352 - Pubmed
- 2.Clark T & Soulen M. Chemical Ablation of Hepatocellular Carcinoma. J Vasc Interv Radiol. 2002;13(9):S245-52. doi:10.1016/s1051-0443(07)61792-8