Chemical ablation

Last revised by Dr Ian Bickle on 01 Jun 2022

Chemical ablation is a technique in which chemical ablative substances are used to cause cell death in neoplastic tissue. It is used as a standalone procedure or in combination with other techniques like TACE and radiofrequency ablation.

  • Absolute ethanol (most commonly used)
  • Acetic acid
  1. Cytotoxic: Chemical substances causes cell death by means of cell membrane damage, protein denaturation and cellular dehydration.
  2. Vascular: agents also cause vascular endothelial damage and thrombosis 2.
  • hepatocellular carcinoma (HCC) 2
  • renal cell carcinoma (RCC1
  • Hematoma : parenchymal and subcapsular hematoma formation
  • Hemoperitoneum
  • Hemobilia
  • Intestinal perforation
  • Cholangitis
  • Hepatic vein thrombosis
  • Portal vein thrombosis
  • Pneumothorax and pleural effusion
  • Hepatic infarct
  • Tumor seeding along the needle track

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