Chemical ablation

Last revised by Nak Hyun Kim on 5 May 2023

Chemical ablation is a technique in which chemical ablative substances are used to cause cell death in neoplastic tissue. It is used as a standalone procedure or in combination with other techniques like TACE and radiofrequency ablation.

  • absolute ethanol (most commonly used)

  • acetic acid

There are broadly two mechanisms of action:

  • cytotoxic: chemical substances cause cell death by means of cell membrane damage, protein denaturation and cellular dehydration.

  • vascular: agents also cause vascular endothelial damage and thrombosis. 2

  • hematoma : parenchymal and subcapsular hematoma formation

  • hemoperitoneum

  • hemobilia

  • intestinal perforation

  • cholangitis

  • hepatic vein thrombosis

  • portal vein thrombosis

  • pneumothorax and pleural effusion

  • hepatic infarct

  • tumor seeding along the needle track

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.