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Chondroblastomas are benign chondrogenic bone neoplasms characteristically arising in the epiphysis or apophysis of a long bone in young patients. Despite being rare, they are one of the most frequently encountered benign epiphyseal neoplasms in skeletally immature patients 1.
Chondroblastoma accounts for one of the 'C's in the popular mnemonic for lucent bone lesions FEGNOMASHIC.
Chondroblastomas represent <1% of all primary bone tumors 1,2 occurring predominantly in the immature skeleton of young patients in the second and early third decade (10-25 years) with an overall male predilection 1-3.
The diagnosis of chondroblastomas is based on a combination of typical radiological and pathological features 1.
Diagnostic criteria according to the WHO classification of soft tissue and bone tumors (5th edition) 1:
Essential criteria are 1:
osteolytic bone tumor in an epiphyseal or apophyseal location
sheets of chondroblasts with interspersed osteoclastic giant cells and eosinophilic chondroid matrix
The following criteria are desirable 1:
network of pericellular chickenwire-calcifications
presence of H3.3 mutation either by H3-3A/H3-3B analysis or by p.Lys.36Met (K36M) expression
Clinical symptoms vary with the location of the tumor and include bone pain, local tenderness, joint effusion with stiffness and restricted motion or muscle atrophy 1-3.
Complications include 1-3:
benign lung metastases (in exceptional cases)
Chondroblastomas are well-defined tumors composed of chondroblastic cells, islands of a chondroid matrix with a sclerotic rim. They usually show an eccentric position in the epiphyses and apophyses of long bones 1.
The etiology of chondroblastomas is not known 1.
Most chondroblastomas occur in the subchondral epiphyseal region of long bones such as the proximal or distal femur, the proximal tibia and proximal humerus 1-3. They can also occur in the talus, calcaneus, patella and pelvic bones e.g the acetabulum and less frequently affect the ribs the spine or small bones of hands and feet 1 or the craniofacial skeleton 2,3. They are usually confined to a single bone.
Grossly chondroblastomas display the following features 1-3:
grayish-yellow appearance with hemorrhage
small calcifications often leading to a gritty and chalky cut surface
sharply demarcated from adjacent bone
aneurysmal bone cyst-like changes or areas of necrosis might be present
Histologically, chondroblastomas are characterized by the following 1:
sheets of intermediate-sized chondroblastic ovoid to polygonal cells with eosinophilic cytoplasm
centrally placed nuclei often with longitudinal nuclear grooves (“coffee bean” nuclei)
possible cellular atypia and occasional mitoses
interspersed osteoclastic giant cells
islands of chondroid matrix
pericellular lace-like "chicken-wire calcification" (pathognomonic)
commonly aneurysmal bone cyst-like changes
The presence of occasional giant multinucleated cells may lead to the incorrect diagnosis of a giant cell tumor.
On immunohistochemistry diffuse nuclear expression of p.Lys36Met (K36M), an antibody against H3.3B is characteristic 1.
Chondroblastomas are characterized by a p.Lys36Met substitution on the H3-3B (H3F3B) or less frequently H3-3A (H3F3A) genes 1.
Chondroblastomas are well-defined lytic bone lesions with geographical bone destruction and thin sclerotic margins. They are usually eccentric epiphyseal or apophyseal located adjacent to the growth plates 1-3. As they grow larger they can extend into the metaphyses. They might be associated with joint effusion. Lesions are usually <5 cm on detection 1,3.
On plain radiographs chondroblastomas display the following characteristics 1,2:
radiolucent bone lesion
internal “fluffy” calcifications in about half of the cases
a narrow zone of transition
bone mineralization, trabeculation
endosteal scalloping, cortical thinning, cortical erosion
rarely cortical breaches with soft tissue invasion
a periosteal reaction in a metadiaphyseal location 4
joint effusion (in up to one-third of patients)
Among epiphyseal lesions, the presence of solid or layered periosteal reaction distant to the lesion (involving the diaphysis) is distinctive for chondroblastoma 7.
On CT chondroblastomas are solitary lucent bone lesions. Features like internal calcifications, cortical involvement and cortical destruction can be more readily assessed than on plain radiography 7,8.
On MRI chondroblastomas usually demonstrate the following features 6-9:
lobular internal architecture
a thin hypointense sclerotic rim on T1 and T2 weighted images
surrounding bone marrow edema
soft tissue edema
possible fluid-fluid levels in the presence of aneurysmal bone cyst-like changes
T1: intermediate signal
T2: variable, heterogeneous intermediate signal intensity
STIR: high signal
T1 C+ (Gd): heterogeneous moderate enhancement together with enhancement of surrounding bone and soft-tissue edema
Chondroblastomas usually demonstrate increased radionuclide uptake 3 in the epiphysis and metaphysis, especially in the uninvolved bone adjacent to the chondroblastoma 7.
The radiological report should include a description of the following 10:
location and size
tumor margins and transition zone
relation to the growth plate and articular surface
cystic and solid tumor components
fluid-fluid levels suggesting aneurysmal bone cyst-like changes
soft tissue extension
aggressive periosteal reaction
surrounding bone marrow edema
solid mass-like enhancement
associated joint effusion
On CT and MRI the lesion can be categorized as Bone-RADS 4 unless histology has been already obtained 10.
Treatment and prognosis
Chondroblastomas are benign tumors. Treatment typically consists of curettage and packing of the resulting cavity and with or without adjuvant therapy 1-3,11-13. Radiofrequency ablation may be used 1,8,11.
Local recurrence is site-specific, higher in flat bones and can happen in up to 18% usually in an interval ranging from 6 months to 8 years 1,2.
Treatment may be also complicated by growth plate injury, which can lead to growth arrest and limb length discrepancy 8.
Benign lung metastases are exceptionally rare 1-3.
History and etymology
A chondroblastoma has been described as a cartilage-containing tumor by Kolodny in 1927 3,4 and as a “calcifying giant cell tumor” by Ewing in 1928 2,4.
In 1931 this lesion was described by the American physician Ernest Armory Codman (1869-1940) as an ‘epiphyseal chondromatous giant cell tumor of the proximal humerus’ of whom it adopted the name Codman tumor 2,3,14.
In 1942 the American pathologists Henry Louis Jaffe (1896-1979) and Louis Lichtenstein (1906-1977) designated this tumor as a benign chondroblastoma of bone 15.
The differential is that of other lesions with a predilection for the epiphysis or apophysis (see differential for an epiphyseal lesion). Specific lesions to be considered include 2,3,16:
giant cell tumor: older age group (closed physis)
- 1. WHO Classification of Tumours Editorial Board. WHO Classification of Tumours, 5th Edition. Soft Tissue and Bone Tumours. (2020) ISBN: 9789283245025 - IARC Publications
- 2. Chen W & DiFrancesco L. Chondroblastoma: An Update. Arch Pathol Lab Med. 2017;141(6):867-71. doi:10.5858/arpa.2016-0281-RS - Pubmed
- 3. De Mattos C, Angsanuntsukh C, Arkader A, Dormans J. Chondroblastoma and Chondromyxoid Fibroma. J Am Acad Orthop Surg. 2013;21(4):225-33. doi:10.5435/JAAOS-21-04-225 - Pubmed
- 4. Kricun M, Kricun R, Haskin M. Chondroblastoma of the Calcaneus: Radiographic Features with Emphasis on Location. AJR Am J Roentgenol. 1977;128(4):613-6. doi:10.2214/ajr.128.4.613 - Pubmed
- 5. Ilaslan H, Sundaram M, Unni K. Vertebral Chondroblastoma. Skeletal Radiol. 2003;32(2):66-71. doi:10.1007/s00256-002-0599-4 - Pubmed
- 6. Weatherall P, Maale G, Mendelsohn D, Sherry C, Erdman W, Pascoe H. Chondroblastoma: Classic and Confusing Appearance at MR Imaging. Radiology. 1994;190(2):467-74. doi:10.1148/radiology.190.2.8284401 - Pubmed
- 7. Brower A, Moser R, Kransdorf M. The Frequency and Diagnostic Significance of Periostitis in Chondroblastoma. AJR Am J Roentgenol. 1990;154(2):309-14. doi:10.2214/ajr.154.2.2105021 - Pubmed
- 8. Erickson J, Rosenthal D, Zaleske D, Gebhardt M, Cates J. Primary Treatment of Chondroblastoma with Percutaneous Radio-Frequency Heat Ablation: Report of Three Cases. Radiology. 2001;221(2):463-8. doi:10.1148/radiol.2212010262 - Pubmed
- 9. Jee W, Park Y, McCauley T et al. Chondroblastoma: MR Characteristics with Pathologic Correlation. J Comput Assist Tomogr. 1999;23(5):721-6. doi:10.1097/00004728-199909000-00016 - Pubmed
- 10. Chang C, Garner H, Ahlawat S et al. Society of Skeletal Radiology- White Paper. Guidelines for the Diagnostic Management of Incidental Solitary Bone Lesions on CT and MRI in Adults: Bone Reporting and Data System (Bone-RADS). Skeletal Radiol. 2022. doi:10.1007/s00256-022-04022-8 - Pubmed
- 11. Suneja R, Grimer R, Belthur M et al. Chondroblastoma of Bone: Long-Term Results and Functional Outcome After Intralesional Curettage. J Bone Joint Surg Br. 2005;87(7):974-8. doi:10.1302/0301-620X.87B7.16009 - Pubmed
- 12. Garin I & Wang E. Chondroblastoma. J Orthop Surg (Hong Kong). 2008;16(1):84-7. doi:10.1177/230949900801600119 - Pubmed
- 13. Deventer N, Deventer N, Gosheger G et al. Chondroblastoma: Is Intralesional Curettage with the Use of Adjuvants a Sufficient Way of Therapy? J Bone Oncol. 2021;26:100342. doi:10.1016/j.jbo.2020.100342 - Pubmed
- 14. Codman E. The Classic: Epiphyseal Chondromatous Giant Cell Tumors of the Upper End of the Humerus. Surg Gynecol Obstet.1931;52:543. Clin Orthop Relat Res. 2006;450:12-6. doi:10.1097/01.blo.0000229309.90265.df - Pubmed
- 15. Jaffe H & Lichtenstein L. Benign Chondroblastoma of Bone: A Reinterpretation of the So-Called Calcifying or Chondromatous Giant Cell Tumor. Am J Pathol. 1942;18(6):969-91. PMC2032980 - Pubmed
- 16. Adam Greenspan, Wolfgang Remagen. Differential Diagnosis of Tumors and Tumor-Like Lesions of Bones and Joints. (1998) ISBN: 9780397517107 - Google Books
- 16. Shigeki Yamamura, Keiji Sato, Hideshi Sugiura, Hirohisa Katagiri, Yoko Ando, Hiroshi Fukatsu, Hisashi Iwata. Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging. (1997) Cancer. 79 (2): 255-61. doi.org/10.1002/(SICI)1097-0142(19970115)79:2<255::AID-CNCR8>3.0.CO;2-J - Pubmed
- 17. Kaim AH, Hügli R, Bonél HM, Jundt G. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. (2002) Skeletal radiology. 31 (2): 88-95. doi:10.1007/s00256-001-0450-3 - Pubmed