Chromium-labeled red blood cells

Chromium-labeled red blood cells is an intravascular MRI contrast agent. The use of 51Cr-labeled RBCs in nuclear medicine suggested the use of paramagnetic Cr(III)-labeled RBCs as an intravascular contrast agent for MRI. In dogs, significant enhancement of the liver and spleen is noted with minimal enhancement of the kidneys. The blood volume to be replaced with labeled RBCs in these studies corresponds to about one unit in humans. The survival half-life of labeled cells is 4.7 days compared to 16.6 days for unlabeled cells. Free chromium ions may contribute to the enhanced relaxation rates of the liver and spleen. Short term toxicity appears to be low, but further studies are necessary.

Imaging technology

Article information

rID: 21775
Synonyms or Alternate Spellings:
  • Cr-labeled red blood cells
  • Chromium-labeled RBCs
  • Cr-labeled RBCs
  • Chromium-labeled erythrocytes
  • Cr-labeled erythrocytes

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