Chromium-labeled red blood cells
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At the time the article was created J. Ray Ballinger had no recorded disclosures.View J. Ray Ballinger's current disclosures
At the time the article was last revised Andrew Murphy had no recorded disclosures.View Andrew Murphy's current disclosures
Chromium-labeled red blood cells is an intravascular MRI contrast agent. The use of 51Cr-labeled RBCs in nuclear medicine suggested the use of paramagnetic Cr(III)-labeled RBCs as an intravascular contrast agent for MRI. In dogs, significant enhancement of the liver and spleen is noted with minimal enhancement of the kidneys. The blood volume to be replaced with labeled RBCs in these studies corresponds to about one unit in humans. The survival half-life of labeled cells is 4.7 days compared to 16.6 days for unlabeled cells. Free chromium ions may contribute to the enhanced relaxation rates of the liver and spleen. Short term toxicity appears to be low, but further studies are necessary.
- Eisenberg AD, Conturo TE, Price RR et-al. AUR memorial award-1988. MRI enhancement of perfused tissues using chromium labeled red blood cells as an intravascular contrast agent. Invest Radiol. 1989;24 (10): 742-53. Pubmed citation
- Eisenberg AD, Conturo TE, Mitchell MR et-al. Enhancement of red blood cell proton relaxation with chromium labeling. Invest Radiol. 1986;21 (2): 137-43. Pubmed citation