Chromogranin A

Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurones, as is a member of the granin family of proteins. It can be used both for immunohistochemical stains and as a serum marker 4


Chromogranin A is useful in identifying tissues of neuroendocrine origin, especially neuroendocrine tumours, as well as dysplastic neurones (e.g. in ganglioglioma) 5

Serum biomarker

Chromogranin A can be used to aid detection and surveillance of neuroendocrine tumours.  It can be elevated with:

Serum CgA values can also be used to trend neuroendocrine tumour burden, but caution should be exercised if the patient is being treated with somatostatin analogues, as they may depress CgA levels.

See other tumour markers here.

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Article information

rID: 24662
Section: Pathology
Tag: refs, cases
Synonyms or Alternate Spellings:
  • CgA
  • chromogranin-A

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