Chromogranin A
Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosuresAt the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosures- CgA
- Chromogranin-A
Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurons, as it is a member of the grain family of proteins. It can be used both for immunohistochemical stains and as a serum marker 4.
Pathology
Chromogranin A is useful in identifying tissues of neuroendocrine origin, especially neuroendocrine tumors and dysplastic neurons (e.g. in ganglioglioma) 5.
Markers
Chromogranin A can be used to aid detection and surveillance of neuroendocrine tumors. It can be elevated with ref:
-
malignant gastric neuroendocrine tumors (in particular)
enterochromaffin and pancreatic islet cell tumors
Serum CgA values can also be used to trend neuroendocrine tumor burden. Still, caution should be exercised if the patient is being treated with somatostatin analogs, as they may depress CgA levels ref.
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See also
References
- 1. Campana D, Nori F, Piscitelli L et al. Chromogranin A: Is It a Useful Marker of Neuroendocrine Tumors? J Clin Oncol. 2007;25(15):1967-73. doi:10.1200/JCO.2006.10.1535 - Pubmed
- 2. Syversen U, Ramstad H, Gamme K, Qvigstad G, Falkmer S, Waldum H. Clinical Significance of Elevated Serum Chromogranin A Levels. Scand J Gastroenterol. 2004;39(10):969-73. doi:10.1080/00365520410003362 - Pubmed
- 3. Reiter M, Costello J, Schwope R, Lisanti C, Osswald M. Review of Commonly Used Serum Tumor Markers and Their Relevance for Image Interpretation. J Comput Assist Tomogr. 2015;39(6):825-34. doi:10.1097/RCT.0000000000000297 - Pubmed
- 4. Hendy G, Bevan S, Mattei M, Mouland A. Chromogranin A. Clin Invest Med. 1995;18(1):47-65. - Pubmed
- 5. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK "WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised" ISBN: 9789283244929
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