Chromogranin A

Last revised by Henry Knipe on 8 Mar 2025

Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurons, as it is a member of the grain family of proteins. It can be used both for immunohistochemical stains and as a serum marker 4

Pathology

Chromogranin A is useful in identifying tissues of neuroendocrine origin, especially neuroendocrine tumors and dysplastic neurons (e.g. in ganglioglioma) 5

Markers

Chromogranin A can be used to aid detection and surveillance of neuroendocrine tumors. It can be elevated with ref:

Serum CgA values can also be used to trend neuroendocrine tumor burden. Still, caution should be exercised if the patient is being treated with somatostatin analogs, as they may depress CgA levels ref.

See also

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