Chromogranin A
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At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosuresAt the time the article was last revised Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures- CgA
- chromogranin-A
Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurons, as is a member of the granin family of proteins. It can be used both for immunohistochemical stains and as a serum marker 4.
Immunohistochemistry
Chromogranin A is useful in identifying tissues of neuroendocrine origin, especially neuroendocrine tumors, as well as dysplastic neurons (e.g. in ganglioglioma) 5.
Serum biomarker
Chromogranin A can be used to aid detection and surveillance of neuroendocrine tumors. It can be elevated with:
- pheochromocytoma
- medullary thyroid carcinoma
- enterochromaffin and pancreatic islet cell tumors
- autoimmune chronic atrophic gastritis
- gastrinoma
- multiple endocrine neoplasia syndrome type 1
- carcinoid tumors: especially malignant gastric carcinoid tumors
Serum CgA values can also be used to trend neuroendocrine tumor burden, but caution should be exercised if the patient is being treated with somatostatin analogs, as they may depress CgA levels.
See other tumor markers here.
References
- 1. Campana D, Nori F, Piscitelli L et-al. Chromogranin A: is it a useful marker of neuroendocrine tumors?. J. Clin. Oncol. 2007;25 (15): 1967-73. J. Clin. Oncol. (full text) - doi:10.1200/JCO.2006.10.1535 - Pubmed citation
- 2. Syversen U, Ramstad H, Gamme K et-al. Clinical significance of elevated serum chromogranin A levels. Scand. J. Gastroenterol. 2004;39 (10): 969-73. doi:10.1080/00365520410003362 - Pubmed citation
- 3. Reiter MJ, Costello JE, Schwope RB et-al. Review of Commonly Used Serum Tumor Markers and Their Relevance for Image Interpretation. J Comput Assist Tomogr. 2015;39 (6): 825-34. doi:10.1097/RCT.0000000000000297 - Pubmed citation
- 4. Hendy GN, Bevan S, Mattei MG, Mouland AJ. Chromogranin A. Clinical and investigative medicine. Medecine clinique et experimentale. 18 (1): 47-65. Pubmed
- 5. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK "WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised" ISBN: 9789283244929
Incoming Links
- Gangliocytoma
- Pilomyxoid astrocytoma
- Carcinoid tumor
- Cauda equina neuroendocrine tumour
- Pancreatic neuroendocrine tumours
- Ectomesenchymoma
- Paraganglioma
- Diffuse midline glioma, H3 K27-altered
- Gastrinoma
- Large cell neuroendocrine carcinoma of the prostate
- Ganglioglioma
- Well-differentiated neuroendocrine tumour of the prostate
- Angiocentric glioma
- Pineoblastoma
- Tumour markers
- Pineocytoma
- Krenning score of neuroendocrine tumour uptake
- Adenocarcinoma of the prostate with neuroendocrine differentiation
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