Chromophobe renal cell carcinoma

Last revised by Dr Joshua Yap on 18 May 2022

Chromophobe renal cell carcinoma is one of the less common subtypes of renal cell carcinoma (RCC).

This is the least common major subtype of RCC, occurring 5% of the time 1. Similar incidence in men and women. There is an association with Birt-Hogg-Dubé syndrome 4.

This type of RCC arises from intercalated cells of collecting ducts 1,2. The designation "chromophobe" arises because the tumor cells are less translucent than clear cell renal cell carcinomas during staining for histology 1. They have a similar origin to oncocytomas 3.

  • presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on color Doppler imaging
  • relatively homogeneous contrast enhancement
  • isointense to kidney / maybe T2 hypointense
  • relatively homogeneous contrast enhancement
  • necrosis not common

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Cases and figures

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