Chronic hereditary lymphedema
Chronic hereditary lymphedema or Milroy disease is a condition characterised by lower-limb lymphedema. Patients typically present as pedal edema at (or before) birth or developing soon after. Occasionally it develops later in life.
Mutations in the FLT4 gene is thought to be present in some cases. It is usually inherited in an autosomal dominant manner.
History and etymology
It is thought to have been first described by Letessier in 1865 1.
- 1. Hurwitz PA, Pinals DJ. Pleuerla effusions in in chronic hereditary lymphedema (Nonne, Milroy, Meige's disease). Report of two cases. Radiology. 1964;82 (2): 246-8. doi:10.1148/82.2.246 - Pubmed citation
- 2. Gamba JL, Silverman PM, Ling D et-al. Primary lower extremity lymphedema: CT diagnosis. Radiology. 1983;149 (1): 218. doi:10.1148/radiology.149.1.6611927 - Pubmed citation
- 3. Becker C, Arrive L, Saaristo A et-al. Surgical treatment of congenital lymphedema. Clin Plast Surg. 2012;39 (4): 377-84. doi:10.1016/j.cps.2012.08.001 - Pubmed citation