Chronic hereditary lymphedema

Chronic hereditary lymphedema or Milroy disease is a condition characterised by lower-limb lymphedema. Patients typically present with pedal oedema at or before birth or soon after. Occasionally, it develops later in life.

Pathology

Genetics

Mutations in the FLT4 gene is thought to be present in some cases. It is usually inherited in an autosomal dominant pattern.

History and etymology

It is thought to have first been described by Letessier in 1865 1.

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Article information

rID: 35015
Section: Syndromes
Tag: cases
Synonyms or Alternate Spellings:
  • Chronic hereditary lymphoedema
  • Milroy disease
  • Nonne disease
  • Congenital lymphedema
  • Congenital lymphoedema
  • Nonne-Milroy hereditary lymphedema

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