Chronic hereditary lymphedema

Chronic hereditary lymphedema or Milroy disease is a condition characterised by lower-limb lymphedema. Patients typically present as pedal edema at (or before) birth or developing soon after. Occasionally it develops later in life.



Mutations in the FLT4 gene is thought to be present in some cases. It is usually inherited in an autosomal dominant manner.

History and etymology

It is thought to have been first described by Letessier in 1865 1.

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Article Information

rID: 35015
Synonyms or Alternate Spellings:
  • Chronic hereditary lymphoedema
  • Milroy disease
  • Nonne disease
  • Congenital lymphedema
  • Congenital lymphoedema

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