Chronic hereditary lymphedema (also known as Milroy disease) is a condition characterized by lower limb lymphedema. Patients typically present with pedal edema at or before birth or soon after. Occasionally, it develops later in life.
Mutations in the FLT4 gene are thought to be present in some cases. It is usually inherited in an autosomal dominant pattern.
History and etymology
It is thought to have first been described by Letessier in 1865 1.
- 1. Hurwitz PA, Pinals DJ. Pleural effusions in in chronic hereditary lymphedema (Nonne, Milroy, Meige's disease). Report of two cases. Radiology. 1964;82 (2): 246-8. doi:10.1148/82.2.246 - Pubmed citation
- 2. Gamba JL, Silverman PM, Ling D et-al. Primary lower extremity lymphedema: CT diagnosis. Radiology. 1983;149 (1): 218. doi:10.1148/radiology.149.1.6611927 - Pubmed citation
- 3. Becker C, Arrive L, Saaristo A et-al. Surgical treatment of congenital lymphedema. Clin Plast Surg. 2012;39 (4): 377-84. doi:10.1016/j.cps.2012.08.001 - Pubmed citation