Cirrhosis (CNS manifestations)

Last revised by Henry Knipe on 18 Jun 2020

There are several central nervous system complications that can arise in the setting of cirrhosis, which can be classified as those which are general (essentially hepatic encephalopathy) and those that are specific to the cause of cirrhosis.

General manifestations

The major manifestation is hepatic encephalopathy which can be subdivided into:

  • acute hepatic encephalopathy which is a rare syndrome due to hyperammonemia and is potentially reversible, and
  • chronic hepatic encephalopathy which is far more common and secondary to cirrhosis

Disease-specific manifestations

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