Classification of ductal carcinoma in situ (DCIS)
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The new pathological classification of DCIS is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:
Low grade:
- round, regular to mildly irregular nuclei up to 2-3 times the size of a red blood cell
- no comedo necrosis
Intermediate grade:
- round, regular to mildly irregular nuclei up to 2-3 times the size of a red blood cell
- substantial comedo necrosis
High grade
- pleomorphic nuclei more than 3 times the size of a red blood cell
- substantial comedo necrosis usually present, but not required for the diagnosis
-<p>The new pathological classification of DCIS is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:</p><p><strong>Low grade:</strong></p><ul>- +<p>The new pathological classification of <a title="Ductal carcinoma in situ (DCIS)" href="/articles/ductal-carcinoma-in-situ">DCIS </a>is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:</p><p><strong>Low grade</strong></p><ul>
-</ul><p><strong>Intermediate grade:</strong></p><ul>- +</ul><p><strong>Intermediate grade</strong></p><ul>
References changed:
- 1. Pinder SE. Ductal carcinoma in situ (DCIS): pathological features, differential diagnosis, prognostic factors and specimen evaluation. Mod. Pathol.23 Suppl 2: S8-13. <a href="http://dx.doi.org/doi:10.1038/modpathol.2010.40">doi:doi:10.1038/modpathol.2010.40</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/20436505">Pubmed citation</a><span class="auto"></span>
- 2. Fadare O, Clement NF, Ghofrani M. High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision. Diagn Pathol. 2009;4 (1): 26. <a href="http://dx.doi.org/10.1186/1746-1596-4-26">doi:10.1186/1746-1596-4-26</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740842">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/19691836">Pubmed citation</a><span class="auto"></span>
Sections changed:
- Classifications
Systems changed:
- Breast