Citation, DOI, disclosures and article data
At the time the article was created Ahmed Abdrabou had no recorded disclosures.View Ahmed Abdrabou's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
Clinical picture is characteristic and includes ipsilateral oculomotor nerve palsy and contralateral upper and lower limb ataxia 1-4.
Claude syndrome is generally caused by an ischemic stroke secondary to occlusion of the small perforating branches of the posterior cerebral artery supplying the dorsomedial aspect of the midbrain 1-4. The infarction involves the medial aspect of the red nucleus with the rubrodentate fibers, CN III nucleus and superior cerebellar peduncle 1-4.
History and etymology
The syndrome was first described by Henri Claude (1869-1945), a French neurologist, in 1912 5.
- 1. Seo SW, Heo JH, Lee KY, Shin WC, Chang DI, Kim SM, Heo K. Localization of Claude's syndrome. Neurology. 57 (12): 2304-7. Pubmed
- 2. Fong CS. Claude's syndrome associated with supranuclear horizontal gaze palsy caused by dorsomedial midbrain infarction. Acta Neurol Taiwan. 2005;14 (3): 147-50. Pubmed citation
- 3. Ropper AH, Samuels MA, Klein JP. Adams and Victor's principles of neurology 10th ed. New York: McGraw-Hill Medical Pub. Division; 2014.
- 4. Liu GT, Crenner CW, Logigian EL, Charness ME, Samuels MA. Midbrain syndromes of Benedikt, Claude, and Nothnagel: setting the record straight. Neurology. 42 (9): 1820-2. Pubmed
- 5. Claude H. Syndrome pedonculaire de la region du noyau rouge. Rev Neurol (Paris) 1912;1(23):311-313.