Claude syndrome
Last revised by Dr Daniel J Bell ◉ on 09 Mar 2018
Citation, DOI & article data
Citation:
Abdrabou, A., Bell, D. Claude syndrome. Reference article, Radiopaedia.org. (accessed on 06 Oct 2022) https://doi.org/10.53347/rID-32267
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rID:
32267
Article created:
22 Nov 2014 by Dr Ahmed Abdrabou
Revisions:
5 times by 4 users - see full revision history
System:
Section:
Synonyms:
- Claude's syndrome
Claude syndrome is one of the brainstem stroke syndromes in which there is infarction of the dorsomedial aspect of the midbrain.
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Clinical presentation
Clinical picture is characteristic and includes ipsilateral oculomotor nerve palsy and contralateral upper and lower limb ataxia 1-4.
Pathology
Claude syndrome is generally caused by an ischemic stroke secondary to occlusion of the small perforating branches of the posterior cerebral artery supplying the dorsomedial aspect of the midbrain 1-4. The infarction involves the medial aspect of the red nucleus with the rubrodentate fibers, CN III nucleus and superior cerebellar peduncle 1-4.
History and etymology
The syndrome was first described by Henri Claude (1869-1945), a French neurologist, in 1912 5.
References
- 1. Seo SW, Heo JH, Lee KY, Shin WC, Chang DI, Kim SM, Heo K. Localization of Claude's syndrome. Neurology. 57 (12): 2304-7. Pubmed
- 2. Fong CS. Claude's syndrome associated with supranuclear horizontal gaze palsy caused by dorsomedial midbrain infarction. Acta Neurol Taiwan. 2005;14 (3): 147-50. Pubmed citation
- 3. Ropper AH, Samuels MA, Klein JP. Adams and Victor's principles of neurology 10th ed. New York: McGraw-Hill Medical Pub. Division; 2014.
- 4. Liu GT, Crenner CW, Logigian EL, Charness ME, Samuels MA. Midbrain syndromes of Benedikt, Claude, and Nothnagel: setting the record straight. Neurology. 42 (9): 1820-2. Pubmed
- 5. Claude H. Syndrome pedonculaire de la region du noyau rouge. Rev Neurol (Paris) 1912;1(23):311-313.
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