Clear cell carcinoma of the cervix

Last revised by Dr Mark Thurston on 21 Feb 2018

Clear cell carcinoma of the cervix (CCCC) is a rare adenocarcinoma subtype of cervical cancer.

Due to association with diethylstilbestrol (DES) exposure in some patients, this subtype may have a younger age at presentation than other histological subtypes. This subtype can sometimes present in the pediatric age group 5.

The tumor can have solid, tubulocystic or papillary patterns 3.

  • in utero DES exposure in some patients ( ~6%) 2
  • no association with HPV DNA (unlike other cervical cancer subtypes) 4

In selected cases (particularly pediatric patients), radical trachelectomies have been carried out with fertility sparing 4-5.

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