Clear cell papillary renal cell carcinoma is a subtype renal cell carcinoma.
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Epidemiology
Generally uncommon but thought to be the fourth most common histologic type of renal cell carcinoma at the time of new classification (c. 2016) 1.
Pathology
This subtype is characterized by low-grade, clear cells, showing papillary and tubular architecture 2.
Markers
- has shown to demonstrate expression of GATA3 5
Radiographic features
Two imaging patterns have been described including cystic and solid in almost equal proportions.
MRI
All solid tumors tend to show:
- T2: hyperintense compared with renal cortex
- T1 C+: maximal enhancement on corticomedullary phase with a delayed washout
Prognosis
This subtype is generally thought to have indolent behavior with low malignant potential.
History and etymology
Clear cell papillary renal cell carcinoma was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013 and then added to the World Health Organizatiοn Classification of Tumors of the Urinary System and Male Genital Organs in 2016 3.
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