Clear cell papillary renal cell carcinoma

Last revised by Daniel J Bell on 4 Oct 2021

Clear cell papillary renal cell carcinoma is a subtype renal cell carcinoma.

Generally uncommon but thought to be the fourth most common histologic type of renal cell carcinoma at the time of new classification (c. 2016) 1.

This subtype is characterized by low-grade, clear cells, showing papillary and tubular architecture 2

  • has shown to demonstrate expression of GATA3 5

Two imaging patterns have been described including cystic and solid in almost equal proportions. 

All solid tumors tend to show:

  • T2: hyperintense compared with renal cortex
  • T1 C+: maximal enhancement on corticomedullary phase with a delayed washout

This subtype is generally thought to have indolent behavior with low malignant potential.

Clear cell papillary renal cell carcinoma was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013 and then added to the World Health Organizatiοn Classification of Tumors of the Urinary System and Male Genital Organs in 2016 3.

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