Clinically isolated syndrome
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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
At the time the article was last revised Mert Bayramoglu had no recorded disclosures.View Mert Bayramoglu's current disclosures
Clinically isolated syndrome (CIS) is the first episode suggestive of demyelination 1,2. It can either be monofocal (single lesion) or multifocal 1,2. Not all patients with CIS will go on to develop multiple sclerosis however if at presentation there are changes on MRI suggestive of MS, then the chances of progressing to MS are high 1.
Latest McDonalds criteria (2017) allows an early diagnosis to be made solely on basis of dissemination in space on MRI, and the presence of CSF-specific oligoclonal bands, without the need for demonstration of dissemination in time on MRI.
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- 2. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. (2017) The Lancet. Neurology. doi:10.1016/S1474-4422(17)30470-2 - Pubmed