Clinically isolated syndrome
Last revised by Mert Bayramoglu on 12 Jan 2019
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Bayramoglu M, Sharma R, et al. Clinically isolated syndrome. Reference article, Radiopaedia.org (Accessed on 03 Oct 2023) https://doi.org/10.53347/rID-1135
Permalink:
rID:
1135
Article created:
Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosuresLast revised:
12 Jan 2019, Mert Bayramoglu
Disclosures:
At the time the article was last revised Mert Bayramoglu had no recorded disclosures.
View Mert Bayramoglu's current disclosuresRevisions:
15 times, by 7 contributors - see full revision history and disclosures
Systems:
Synonyms:
- Clinically isolated syndrome (CIS)
Clinically isolated syndrome (CIS) is the first episode suggestive of demyelination 1,2. It can either be monofocal (single lesion) or multifocal 1,2. Not all patients with CIS will go on to develop multiple sclerosis however if at presentation there are changes on MRI suggestive of MS, then the chances of progressing to MS are high 1.
Latest McDonalds criteria (2017) allows an early diagnosis to be made solely on basis of dissemination in space on MRI, and the presence of CSF-specific oligoclonal bands, without the need for demonstration of dissemination in time on MRI.
References
- 1. Miller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol. 2012;11 (2): 157-69. doi:10.1016/S1474-4422(11)70274-5 - Pubmed citation
- 2. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. (2017) The Lancet. Neurology. doi:10.1016/S1474-4422(17)30470-2 - Pubmed
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