CLOVES syndrome

CLOVE syndrome is an acronym denoting a rare condition consisting of:

  • Congenital Lipomatous Overgrowth
  • Vascular malformations
  • Epidermal nevi
  • Skeletal/Scoliosis/Spinal anomalies

Abnormalities have a truncal predominance.

Associated findings include:

The condition is considered an overgrowth syndrome, similar to, but separate from Proteus syndrome.  It is associated with three different missense mutations in the PIK3CA gene 2.

Although first described as CLOVE the term "CLOVES" syndrome, with the "S" emphasizing the skeletal abnormalities associated with the condition, is now preferred. 

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Article information

rID: 32261
System: Paediatrics
Section: Syndromes
Synonyms or Alternate Spellings:
  • Congenital lipomatous overgrowth
  • CLOVES syndrome

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