Cluster of black pearls sign
Updates to Article Attributes
ThisThe cluster of black pearls sign refers to the presence of tiny round nodules (1- 2 mm) distributed uniformly within the whole or part of the homogenously enhancing lymph node in the venous phase (70 sec delay after contrast administration) of thin-section contrast-enhanced multidetector CT study. This sign It is an accurate morphological sign differentiating sarcoid from other adenopathy such astuberculosis, lymphoma and metaststicmetastatic adenocarcinoma nodes. This sign has 83% sensitivity, 98% specificity, 91% positive predictive value, and 96% negative predictive value on a per node basis and a sensitivity of 100% on a per patient basis in the diagnosis of sarcoidosis1.
When combined with other characteristics of homogeneous contrast enhancement of 60-80 HU, ovoid shape, sharp margins along with absence of perinodal haziness, calcification, and necrosis, it can be highly accurate for sarcoid adenopathy.
-<p>This sign refers to the presence of tiny round nodules (1- 2 mm) distributed uniformly within the whole or part of the homogenously enhancing lymph node in the venous phase (70 sec delay after contrast administration) of thin-section contrast-enhanced multidetector CT study. This sign is an accurate morphological sign differentiating sarcoid from other adenopathy such as tuberculosis, lymphoma and metaststic adenocarcinoma nodes. This sign has 83% sensitivity, 98% specificity, 91% positive predictive value, and 96% negative predictive value on a per node basis and a sensitivity of 100% on a per patient basis. </p><p> When combined with other characteristics of homogeneous contrast enhancement of 60-80 HU, ovoid shape, sharp margins along with absence of perinodal haziness, calcification, and necrosis, it can be highly accurate for sarcoid adenopathy.</p>- +<p><strong>The cluster of black pearls sign</strong> refers to the presence of tiny round nodules (1- 2 mm) distributed uniformly within the whole or part of the homogenously enhancing lymph node in the venous phase (70 sec delay after contrast administration) of thin-section contrast-enhanced multidetector CT study. It is an accurate morphological sign differentiating <a href="/articles/sarcoidosis-thoracic-manifestations-2">sarcoid</a> from other adenopathy such as tuberculosis, lymphoma and metastatic adenocarcinoma nodes. This sign has 83% sensitivity, 98% specificity, 91% positive predictive value, and 96% negative predictive value on a per node basis and a sensitivity of 100% on a per patient basis in the diagnosis of <a href="/articles/sarcoidosis-1">sarcoidosis</a><sup>1</sup>. </p><p> When combined with other characteristics of homogeneous contrast enhancement of 60-80 HU, ovoid shape, sharp margins along with absence of perinodal haziness, calcification, and necrosis, it can be highly accurate for sarcoid adenopathy.</p>
References changed:
- 1. Venkata Ramanan R, Pudhiavan A, Venkataramanan A. The "cluster of black pearls" sign of sarcoid lymphadenopathy: a new sign on thin-section contrast-enhanced multidetector CT. (2017) Clinical radiology. 72 (9): 729-736. <a href="https://doi.org/10.1016/j.crad.2017.03.031">doi:10.1016/j.crad.2017.03.031</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/28655404">Pubmed</a> <span class="ref_v4"></span>
Sections changed:
- Signs
Systems changed:
- Chest