Colloid nodule (thyroid)

Last revised by Joshua Yap on 10 Oct 2022

Colloid nodules are non-neoplastic benign nodules occurring within the thyroid gland. They form the vast majority of nodular thyroid disease.


Colloid nodules are composed of irregularly enlarged follicles containing abundant colloid. A colloid nodule may be single or multiple and can vary considerably in size.

Some colloid nodules can be cystic (cystic colloid nodule) and may contain areas of necrosis, hemorrhage and/or calcification. 

Calcification may represent prior multinodular goiter hemorrhage.

Radiographic features

Plain radiograph
  • calcification in the thyroid secondary to prior hemorrhage

  • tracheal deviation


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Cases and figures

  • Case 1
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  • Case 2: with cystic degeneration
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  • Case 3
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  • Case 4
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