Colloid nodules are non-neoplastic benign nodules occurring within the thyroid gland. They form the vast majority of nodular thyroid disease.
Pathology
Colloid nodules are composed of irregularly enlarged follicles containing abundant colloid. A colloid nodule may be single or multiple and can vary considerably in size.
Some colloid nodules can be cystic (cystic colloid nodule) and may contain areas of necrosis, hemorrhage and/or calcification.
Calcification may represent prior multinodular goiter hemorrhage.
Radiographic features
Plain radiograph
calcification in the thyroid secondary to prior hemorrhage
tracheal deviation
Ultrasound
iso- to hypoechoic
may have internal cystic or heterogeneous change
may have calcification
multiple echogenic foci (of inspissated colloid) with comet tail artifact 4
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