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Common variable immunodeficiency (pulmonary manifestations)

Last revised by Liz Silverstone ◉ ◈ on 7 Jan 2025

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Silverstone L, Di Muzio B, et al. Common variable immunodeficiency (pulmonary manifestations). Reference article, Radiopaedia.org (Accessed on 13 Mar 2025) https://doi.org/10.53347/rID-39879

DOI:

https://doi.org/10.53347/rID-39879

Permalink:

https://radiopaedia.org/articles/39879?embed_domain=hackmd.io%2525252525252f%25252525252540yipuafecsl2jsu8smr5njq%2525252525252fbnjhjgjghjghjgh

rID:

39879

Article created:

25 Sep 2015, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

7 Jan 2025, Liz Silverstone ◉ ◈

Disclosures:

At the time the article was last revised Liz Silverstone had no financial relationships to ineligible companies to disclose.

View Liz Silverstone's current disclosures

Revisions:

7 times, by 6 contributors - see full revision history and disclosures

Systems:

Chest

Tags:

refs

Synonyms:

Pulmonary manifestations of common variable immunodeficiency
Pulmonary manifestations of common variable immunodeficiency (CVID)
Common variable immunodeficiency (thoracic manifestations)
Common variable immunodeficiency (chest manifestations)

Pulmonary manifestations of common variable immunodeficiency can be variable. The respiratory system is one of the most commonly affected systems in common variable immunodeficiency (CVID).

Radiographic features

CT

The spectrum of findings seen in the chest include:

bronchiectasis with interstitial lung disease (e.g. granulomatous-lymphocytic interstitial lung disease)
- could either be due to repeated lung infection or manifestation of dysregulated lymphoid proliferation ¹
- bronchiectasis has been reported as up to 65% of patients according to one study ²
- ~10% of patients with common variable immunodeficiency have a systemic granulomatous disease with associated interstitial lung disease ⁵
pulmonary nodules
ground glass changes
lung parenchymal opacification: may be multifocal
other features
- intrathoracic or intra-abdominal lymphadenopathy and/ or hepatosplenomegaly

References

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