Conotruncal cardiac anomalies
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At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
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Conotruncal heart defects are a group of congenital cardiovascular anomalies involving the outflow tracts and great vessels. They are a leading cause of symptomatic cyanotic cardiac disease diagnosed in utero.
They may account for up to a fifth of all congenital cardiac anomalies diagnosed prenatally 2.
- 22q deletion syndrome: conotruncal anomalies are a frequent component of this syndrome
- maternal diabetes
Due to parallel fetal circulation, these are well tolerated in utero. Affected individuals present with acute hypoxia within the first few days following delivery. In the present day and age, most are detected on in utero ultrasound.
They are usually defined as malformations of the cardiac outflow tracts and presumably result from either a disturbance of the outflow tract of the embryonic heart, or impaired development of the branchial arch and arteries, or both.
This class of defects includes: