Constrictive pericarditis

Dr Vikas Shah and Dr Donna D'Souza et al.

Constrictive pericarditis (or perhaps better termed pericardial constriction) is a type of pericarditis which leads to diastolic dysfunction and potentially symptoms of right heart failure

No single demographic is affected as there are numerous causes of constrictive pericarditis. 

Clinical presentation is dominated by restricted diastolic ventricular filling resulting in an increase in diastolic pressure in all four cardiac chambers. Patients typically present with symptoms of both left and right sided heart failure including:

Characterized by fibrous or calcific constrictive thickening of the pericardium, which prevents normal diastolic filling of the heart. It may follow any type of pericardial effusion and may develop within a variable time frame ranging from two or three months to a number of years.

In approximately 50% of cases there is visible pericardial calcification on chest radiographs. 

Although a thickened pericardium is often present, transthoracic insonation rarely allows satisfactory visualization; the presence of a pleural or pericardial effusion may provide an adequate window, although the latter may further obscure landmarks if sufficiently exudative.

Conversely, a thin and smooth, but highly non-compliant, pericardium may also be present. The hemodynamic consequences of constriction occur due to the pericardium insulating the cardiac chambers from changes in intra-thoracic pressure, although lesser degrees of constriction may occur. 9

Exaggerated ventricular interdependence and intrathoracic-intracardiac dissociation. The pathognomonic finding is respirophasic septal shifting with a characteristic "shudder" due to alternate rapid early filling of the ventricles

  • plethoric inferior vena cava with absent respirophasic variation
  • abrupt, eccentric inflection with flattening of left ventricular lateral wall in early diastole
    • represents tethering to adherent pericardium
    • may result in lateral mitral annulus e' to appear disproportionately low when compared to septal e'
      • phenomenon referred to as "annulus reversus" 11
  • abnormal septal motion
    • characteristic finding is exaggerated respirophasic septal shifts
      • characteristic "shudder" due to the alternate rapid early filling of the ventricles

Spectral Doppler

  • mitral valve inflow demonstrates an inappropriately elevated E/A ratio
    • deceleration time <160 ms
  • mitral and/or tricuspid valve inflow patterns demonstrate pronounced respiratory variation in E-wave velocity
    • >25% variance in peak velocity considered excessive
    • tricuspid inflow is augmented during inspiration and reduced during expiration, while the mitral valve demonstrates the opposite

CT is very sensitive in demonstrating calcification of the pericardium which is suggestive of the disease if found in the proper clinical setting. A thickened pericardium (more than 4 mm) on its own does not indicate constrictive pericarditis 8. Contrast-enhanced CT may also show signs of cardiac failure like septal flattening and retrograde flow of contrast into the dilated inferior vena cava and hepatic veins.

The pericardium is often thickened to more than 4 mm. MRI is better than CT at differentiating between pericardial fluid and thickened pericardium 8. Cine MRI may also demonstrate septal flattening and septal bounce.

Constrictive pericarditis is potentially curable by a pericardiectomy.

Clinically, it is difficult to differentiate between constrictive pericarditis and restrictive cardiomyopathy. It is important to distinguish between constrictive pericarditis and restrictive cardiomyopathy as the former benefit from pericardial stripping.

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rID: 1169
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Pericardial constriction

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