Contrast enhanced mammography (CEM) is a complementary breast imaging modality. A finite number of sequential images are obtained with X-ray beam produced at a high energy, above the K-edge of Iodine, and with an intravenous non-ionic Iodine contrast agent injected between pre and post contrast image acquisitions, to show the flow of the contrast agent over time. As the rapidly growing tumors require an increased supply of blood to support their growth, the contrast agent preferentially accumulates in such areas exhibiting a rapid wash-in and wash-out of iodine, while benign tissues have a slow uptake of the iodine over the time of study duration.
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